Ligases
Ligases (EC 6.-.-.-) form a major class of enzymes that catalyze the ligation (i.e. linking together) of two molecules with concomitant hydrolysis of the pyrophosphate bond in adenosine 5'-triphosphate (ATP) or a similar triphosphate, forming C–C , C–O , C–S , P–O or C–N bonds[1]. Originally, biochemical nomenclature distinguished synthetases and synthases. Under the original definition, synthases do not use energy from nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), whereas synthetases do use nucleoside triphosphates. It is also said that a synthase is a lyase (a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure) and does not require any energy, whereas a synthetase is a ligase (a ligase is an enzyme that binds two chemicals or compounds) and thus requires energy. However, the Joint Commission on Biochemical Nomenclature (JCBN) dictates that "synthase" can be used with any enzyme that catalyses synthesis (whether or not it uses nucleoside triphosphates), whereas "synthetase" is to be used synonymously.
[1] A. D. McNaught, A. Wilkinson. IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Blackwell Scientific Publications,Oxford (1997).
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2639 | AMG 232 | Potent, selective, and orally bioavailable MDM2-p53 inhibitor | €120.00 | |
3194 | Apcin | Inhibitor of APC/C-Cdc20 | €110.00 | |
3898 | BC-1215 | Selective and reversible Fbxo3 inhibitor | €99.00 | |
3108 | BC-LI-0186 | Specific inhibitor of the LRS-RagD interaction | €90.00 | |
3211 | BC1618 | Potent, orally bioavailable, and metabolically stable Fbxo48 inhibitor | €120.00 | |
3846 | C25-140 | First-in-class TRAF6–Ubc13 inhibitor | €160.00 | |
3763 | CFT-7455 | Orally active monofunctional degrader for IKZF1/3 | Inquire | |
2935 | COH000 | First-in-class, highly specific, covalent allosteric inhibitor of SUMO E1 | €175.00 | |
3292 | dCeMM1 | Glue degrader of RBM39 | €110.00 | |
3293 | dCeMM2 | Glue degrader of Cyclin K | €100.00 | |
3709 | DKM 2-93 | Selective inhibitor of UBA5 | €70.00 | |
3765 | DS-3032 | Orally available, potent and selective inhibitor of the p53-MDM2 interaction | Inquire | |
3613 | EN219 | Covalent RNF114 ligand | €120.00 | |
4106 | FX12 | Selective inhibitor and degrader of RNF5 E3 ubiquitin ligase | €110.00 | |
1643 | HLI 373 | HDM2 inhibitor | €100.00 | |
3064 | HOIPIN 11a | Selective, cell-permeable and covalent inhibitor of RBR E3 ubiquitin ligase HOIP | €180.00 | |
2972 | HOIPIN-8 | Potent linear ubiquitin chain assembly complex (LUBAC) inhibitor | €130.00 | |
1538 | JNJ 26854165 | HDM2 inhibitor | €105.00 | |
1586 | JNJ 26854165 dihydrochloride | HDM2 inhibitor | €105.00 | |
2939 | JTP 0819958 | Selective linear ubiquitin chain assembly complex (LUBAC) inhibitor | €125.00 | |
2947 | JTP 1048196 | Prodrug of JTP 0819958; LUBAC inhibitor | €125.00 | |
2549 | L67 | Cytotoxic inhibitor of DNA ligase I and III | €90.00 | |
4143 | MG degrader compound E14 | Potent molecular glue degrader targeting IKZF1/3, GSPT1 and 2 | Recently added | €130.00 |
3109 | ML-792 | Potent and selective inhibitor of SUMO-activating enzyme (SAE) | €145.00 | |
2038 | MLN4924 | Inhibitor of NEDD8 Activating Enzyme (NAE) | €60.00 | |
3829 | MLN7243 | Cell permeable small molecule inhibitor targeting ubiquitin-activating enzymes (UAE, also known as E1 enzymes) | Inquire | |
3466 | MT-802 | Potent and rapid degrader of BTK; PROTAC | €280.00 | |
3816 | N-Carbamyl-L-glutamic acid | CPS1 activator | €80.00 | |
2565 | N106 | Activator of E1 ligase mediated SERCA2a SUMOylation | €95.00 | |
1585 | Nutlin-3 | MDM2 inhibitor (p53 specific) | €95.00 |