Ligases

Ligases (EC 6.-.-.-) form a major class of enzymes that catalyze the ligation (i.e. linking together) of two molecules with concomitant hydrolysis of the pyrophosphate bond in adenosine 5'-triphosphate (ATP) or a similar triphosphate, forming C–C , C–O , C–S , P–O or C–N bonds[1]. Originally, biochemical nomenclature distinguished synthetases and synthases. Under the original definition, synthases do not use energy from nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), whereas synthetases do use nucleoside triphosphates. It is also said that a synthase is a lyase (a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure) and does not require any energy, whereas a synthetase is a ligase (a ligase is an enzyme that binds two chemicals or compounds) and thus requires energy. However, the Joint Commission on Biochemical Nomenclature (JCBN) dictates that "synthase" can be used with any enzyme that catalyses synthesis (whether or not it uses nucleoside triphosphates), whereas "synthetase" is to be used synonymously.


[1] A. D. McNaught, A. Wilkinson. IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Blackwell Scientific Publications,Oxford (1997).

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Axon ID Name Description From price
2639 AMG 232 Potent, selective, and orally bioavailable MDM2-p53 inhibitor €115.00
1643 HLI 373 HDM2 inhibitor €95.00
1538 JNJ 26854165 HDM2 inhibitor €105.00
1586 JNJ 26854165 dihydrochloride HDM2 inhibitor €105.00
2549 L67 Cytotoxic inhibitor of DNA ligase I and III €90.00
2038 MLN 4924 Inhibitor of NEDD8 Activating Enzyme (NAE) €85.00
2565 N106 Activator of E1 ligase mediated SERCA2a SUMOylation €95.00
1585 Nutlin-3 MDM2 inhibitor (p53 specific) €95.00
1880 Nutlin-3a Inhibitor of MDM2 €95.00
1881 Nutlin-3b Less potent (+)-enantiomer of Nutlin-3 €90.00
1953 PRT 4165 E3 Ubiquitin ligase Bmi1/Ring1A inhibitor €70.00
1705 REP 3123 dihydrochloride MetRS inhibitor €125.00
1704 REP 8839 MetRS inhibitor €125.00
2009 RITA Activates p53 through inhibition of MDM2 €105.00
2531 SCR7 pyrazine DNA ligase IV mediated inhibitor of NHEJ €65.00

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