Ligases
Ligases (EC 6.-.-.-) form a major class of enzymes that catalyze the ligation (i.e. linking together) of two molecules with concomitant hydrolysis of the pyrophosphate bond in adenosine 5'-triphosphate (ATP) or a similar triphosphate, forming C–C , C–O , C–S , P–O or C–N bonds[1]. Originally, biochemical nomenclature distinguished synthetases and synthases. Under the original definition, synthases do not use energy from nucleoside triphosphates (such as ATP, GTP, CTP, TTP, and UTP), whereas synthetases do use nucleoside triphosphates. It is also said that a synthase is a lyase (a lyase is an enzyme that catalyzes the breaking of various chemical bonds by means other than hydrolysis and oxidation, often forming a new double bond or a new ring structure) and does not require any energy, whereas a synthetase is a ligase (a ligase is an enzyme that binds two chemicals or compounds) and thus requires energy. However, the Joint Commission on Biochemical Nomenclature (JCBN) dictates that "synthase" can be used with any enzyme that catalyses synthesis (whether or not it uses nucleoside triphosphates), whereas "synthetase" is to be used synonymously.
[1] A. D. McNaught, A. Wilkinson. IUPAC. Compendium of Chemical Terminology, 2nd ed. (the "Gold Book"). Blackwell Scientific Publications,Oxford (1997).
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2639 | AMG 232 | Potent, selective, and orally bioavailable MDM2-p53 inhibitor | €110.00 | |
3194 | Apcin | Inhibitor of APC/C-Cdc20 | €110.00 | |
3108 | BC-LI-0186 | Specific inhibitor of the LRS-RagD interaction | €90.00 | |
2935 | COH000 | First-in-class, highly specific, covalent allosteric inhibitor of SUMO E1 | €175.00 | |
1643 | HLI 373 | HDM2 inhibitor | €95.00 | |
3064 | HOIPIN 11a | Selective, cell-permeable and covalent inhibitor of RBR E3 ubiquitin ligase HOIP | €180.00 | |
2972 | HOIPIN-8 | Potent linear ubiquitin chain assembly complex (LUBAC) inhibitor | €120.00 | |
1538 | JNJ 26854165 | HDM2 inhibitor | €105.00 | |
1586 | JNJ 26854165 dihydrochloride | HDM2 inhibitor | €105.00 | |
2939 | JTP 0819958 | Selective linear ubiquitin chain assembly complex (LUBAC) inhibitor | €125.00 | |
2947 | JTP 1048196 | Prodrug of JTP 0819958; LUBAC inhibitor | €125.00 | |
2549 | L67 | Cytotoxic inhibitor of DNA ligase I and III | €90.00 | |
3109 | ML-792 | Potent and selective inhibitor of SUMO-activating enzyme (SAE) | €145.00 | |
2038 | MLN 4924 | Inhibitor of NEDD8 Activating Enzyme (NAE) | €75.00 | |
2565 | N106 | Activator of E1 ligase mediated SERCA2a SUMOylation | €95.00 |