MetRS

MetRS

Methionine- (or methionyl-) tRNA synthethase (MetRS or MRS, EC 6.1.1.10) belongs to the fairly large family of aminoacyl-tRNA synthetases (ARSs) that catalyze the condensation of a specific amino acid with its cognate tRNA in a reaction that is dependent on ATP. This is the first essential step of protein translation using the genetic code to translate genetic information (in the form of messenger RNA) to produce protein, and is also referred to as tRNA charging. There is at least one ARS enzyme designated for each amino acid. MetRS have long been recognized as potential targets for antibacterial agents (gram positive microbes). Inhibition of a tRNA synthetase essentially mimics starvation for amino acids by lowering the ratio of charged to uncharged tRNA within the cell.

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    1704
    REP 8839
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    REP 3123 dihydrochloride
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More About MetRS

Methionine- (or methionyl-) tRNA synthethase (MetRS or MRS, EC 6.1.1.10)  belongs to the fairly large family of aminoacyl-tRNA synthetases (ARSs) that catalyze the condensation of a specific amino acid with its cognate tRNA in a reaction that is dependent on ATP. This is the first essential step of protein translation using the genetic code to translate genetic information (in the form of messenger RNA) to produce protein, and is also referred to as tRNA charging. There is at least one ARS enzyme designated for each amino acid[1]. MetRS have long been recognized as potential targets for antibacterial agents (gram positive microbes). Inhibition of a tRNA synthetase essentially mimics starvation for amino acids by lowering the ratio of charged to uncharged tRNA within the cell[2].

[1] A. Antonellis, E.D. Green. The Role of Aminoacyl-tRNA Synthetases in Genetic Diseases. Annu. Rev. Genomics Hum. Genet. 2008, 9,87-107.
[2] Mode of Action and Biochemical Characterization ofREP8839, a Novel Inhibitor of Methionyl-tRNA Synthetase. U.A. Ochsner, C.L. Young, K.C. Stone, F.B. Dean, N. Janjic, I.A. Critchley. Antimicrob. Agents Chemother. 2005, 49, 4253-4262.

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