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EN219
- Soluble in DMSO and EtOH
- MF: C17H13Br2ClN2O
- MW: 456.56
Description
EN219 is a moderately selective covalent ligand that targets RNF114 (IC50 value of 470 nM) and mimics nimbolide mode of action. EN219 also inhibited RNF114-mediated autoubiquitination and p21 ubiquitination in vitro.
More Information
| Parent CAS No. | 380351-29-1 |
|---|---|
| Chemical Name | 1-(3,5-Bis(4-bromophenyl)-4,5-dihydro-1H-pyrazol-1-yl)-2-chloroethanone |
| SMILES | O=C(N1N=C(C2C=CC(Br)=CC=2)CC1C1C=CC(Br)=CC=1)CCl |
| MFCD | N.A. |
| InChi | InChI=1S/C17H13Br2ClN2O/c18-13-5-1-11(2-6-13)15-9-16(22(21-15)17(23)10-20)12-3-7-14(19)8-4-12/h1-8,16H,9-10H2 |
| InChiKey | CXRHMHAKZPJNKS-UHFFFAOYSA-N |
| CID | 3413196 |
| Short Description | RNF114 ligand |
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