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dCeMM2
Axon 3293
CAS:
296771-07-8
Purity:
99%
- Soluble in DMSO
- MF: C16H11ClN6OS
- MW: 370.82
Description
dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12:cyclin K with a CRL4B ligase complex. The pronounced destabilization of cyclin K by dCeMM2 occurred alongside a milder destabilization of both associated kinases CDK12 and CDK13.
More Information
| Parent CAS No. | 296771-07-8 |
|---|---|
| Chemical Name | 2-(5H-[1,2,4]Triazino[5,6-b]indol-3-ylthio)-N-(5-chloropyridin-2-yl)acetamide |
| SMILES | N1C2C3=CC=CC=C3NC=2N=C(SCC(NC2C=CC(Cl)=CN=2)=O)N=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H11ClN6OS/c17-9-5-6-12(18-7-9)20-13(24)8-25-16-21-15-14(22-23-16)10-3-1-2-4-11(10)19-15/h1-7H,8H2,(H,18,20,24)(H,19,21,23) |
| InChiKey | VFWVTIHYVUKNGR-UHFFFAOYSA-N |
| CID | 5286209 |
| Short Description | Glue degrader |
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