Bulk Inquiry
Thalidomide
- Soluble in DMSO
- MF: C13H10N2O4
- MW: 258.23
Description
Thalidomide was initially promoted as a sedative with anti-emetic properties. Later, Thalidomide was shown to have immunomodulatory and anti-inflammatory properties in erythema nodosum leprosum (ENL). Moreover, Thalidomide was found to inhibit fibroblast growth factor (bFGF)-induced formation of new blood vessels. Thalidomide targets the CUL4-RBX1-DDB1-CRBN (CRL4CRBN) E3 ubiquitin ligase and promotes the ubiquitination of Ikaros/Aiolos transcription factors by CRL4CRBN.
More Information
| Parent CAS No. | 50-35-1 |
|---|---|
| Chemical Name | 2-(2,6-Dioxopiperidin-3-yl)isoindoline-1,3-dione |
| SMILES | C1C=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=1 |
| MFCD | MFCD00153873 |
| InChi | InChI=1S/C13H10N2O4/c16-10-6-5-9(11(17)14-10)15-12(18)7-3-1-2-4-8(7)13(15)19/h1-4,9H,5-6H2,(H,14,16,17) |
| InChiKey | UEJJHQNACJXSKW-UHFFFAOYSA-N |
| CID | 5426 |
| Short Description | TNFα inhibitor |
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