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Cemsidomide
- CFT7455
Axon 3763
CAS:
2504235-67-8
- Optical Purity: 0.98
- Soluble in DMSO
- MF: C28H27N3O4
- MW: 469.53
Description
Cemsidomide is an orally active monofunctional degrader for IKZF1/3 with picomolar IC50 and DC50, and an immunomodulatory agent.
More Information
| Parent CAS No. | 2504235-67-8 |
|---|---|
| Chemical Name | (S)-3-(6-(4-(Morpholinomethyl)benzyl)-2-oxobenzo[cd]indol-1(2H)-yl)piperidine-2,6-dione |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C=C2C(=O)N([C@H]3CCC(=O)NC3=O)C3C2=C(C(CC2C=CC(CN4CCOCC4)=CC=2)=CC=3)C=1 |&1:6,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C28H27N3O4/c32-25-11-10-24(27(33)29-25)31-23-9-8-20(21-2-1-3-22(26(21)23)28(31)34)16-18-4-6-19(7-5-18)17-30-12-14-35-15-13-30/h1-9,24H,10-17H2,(H,29,32,33)/t24-/m0/s1 |
| InChiKey | MUKCJOOKCZSQNW-DEOSSOPVSA-N |
| CID | 155207651 |
| Short Description | IKZF1/3 degrader |
References
- JA Henderson et al. CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.
- D Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. Patent WO2022032132A1 2022.
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