JAK-STAT

JAKs (Janus Kinase; EC 2.7.10.2; 4 types identified) and STATs (Signal Transducer and Activator of Transcription; 7 types identified) are critical components of many cytokine receptor systems, regulating growth, survival, differentiation and pathogen resistance. (Cytokine) receptor-bound STATs phosphorylated by JAKs dimerize and translocate into the nucleus to regulate target gene transcription. In most cases, a specific JAK-STAT combination has been paired with a specific member of the cytokine receptor family, and this information translated into cell-type specific patterns of cytokine responsiveness and gene expression. Members of the suppressor of cytokine signaling (SOCS) protein family dampen receptor signaling via homologous or heterologous feedback regulation[1],[2]. Consequently, Janus kinase mutations are major molecular events in human hematological malignancies[3].


[1] The JAK-STAT Signaling Pathway: Input and Output Integration. P.J. Murray. J. Immunol. 2007, 178, 2623-2629.
[2] A Road Map for Those Who Don't Know JAK-STAT. D.S. Aaronson, C.M. Horvath. Science 2002, 296, 1653-1655.
[3] Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. O'Sullivan LA, Liongue C, Lewis RS, Stephenson SE, Ward AC. Mol. Immunol. 2007, 44, 2497–506.

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Axon ID Name Description From price
1653 AEE 788 EGFR, ErbB2 and VEGFR tyrosine kinase inhibitor €95.00
1378 AG 490 JAK2 inhibitor €65.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €145.00
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €105.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire
1778 AZ 960 JAK2 inhibitor €95.00
2563 AZD 3759 Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor €85.00
2342 AZD 9291 Potent oral, irreversible, third-generation EGFR TKI with selectivity for mutant EGFRs €95.00
1955 Baricitinib Inhibitor of JAK1 and JAK2 €105.00
1544 BIBW 2992 EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €65.00
2489 Brassinin Dual IDO1/STAT3 inhibitor with antifungal and anticancer activity €75.00
1433 CI 1033 EGFR tyrosine kinase inhibitor €60.00
1338 CP 690550 JAK3 inhibitor €70.00
1537 CP 724714 ErbB-2/HER2 kinase inhibitor €80.00

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