JAK-STAT

JAKs (Janus Kinase; EC 2.7.10.2; 4 types identified) and STATs (Signal Transducer and Activator of Transcription; 7 types identified) are critical components of many cytokine receptor systems, regulating growth, survival, differentiation and pathogen resistance. (Cytokine) receptor-bound STATs phosphorylated by JAKs dimerize and translocate into the nucleus to regulate target gene transcription. In most cases, a specific JAK-STAT combination has been paired with a specific member of the cytokine receptor family, and this information translated into cell-type specific patterns of cytokine responsiveness and gene expression. Members of the suppressor of cytokine signaling (SOCS) protein family dampen receptor signaling via homologous or heterologous feedback regulation[1],[2]. Consequently, Janus kinase mutations are major molecular events in human hematological malignancies[3].


[1] The JAK-STAT Signaling Pathway: Input and Output Integration. P.J. Murray. J. Immunol. 2007, 178, 2623-2629.
[2] A Road Map for Those Who Don't Know JAK-STAT. D.S. Aaronson, C.M. Horvath. Science 2002, 296, 1653-1655.
[3] Cytokine receptor signaling through the Jak-Stat-Socs pathway in disease. O'Sullivan LA, Liongue C, Lewis RS, Stephenson SE, Ward AC. Mol. Immunol. 2007, 44, 2497–506.

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Axon ID Name Description From price
2217 PF 956980 JAK3 inhibitor; analogue of Axon 1338 and 2072 €90.00
2488 Piperlongumine Natural alkaloid with potent cytotoxic activity €65.00
2920 Poziotinib Irreversible pan-HER inhibitor €95.00
2999 RCGD 423 gp130 signalling modulator €125.00
2497 RTA 408 Triterpenoid activator of NRF2 and inhibitor of NF-κB €110.00
1598 Ruxolitinib JAK1 and JAK2 inhibitor €70.00
2666 S-Propargyl-Cysteine Modulator of endogenous hydrogen disulfide €95.00
2313 S3I 201 Potent, cellular STAT3 inhibitor €95.00
2324 SC 144 hydrochloride The first-in-class small-molecule gp130 inhibitor €135.00
1633 SGI 1776 free base Pim kinase inhibitor €95.00
1923 SMI 4a ATP-competitive and selective inhibitor of Pim kinases €75.00
2539 Solcitinib Selective JAK1 inhibitor for treatment of degenerative and inflammatory diseases €90.00
2731 STAT5 Inhibitor 1 [285986-31-4] Nonpeptidic small-molecule inhibitor of STAT5 activation €90.00
2314 Stattic Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation €50.00
1588 TG 101348 JAK2 inhibitor €95.00

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