Cytokines and chemokines are both small proteins made by cells in the immune system. They are important in the production and growth of lymphocytes, and in regulating responses to infection or injury such as inflammation and wound healing. Cytokines are the general category of messenger molecules, while chemokines are a special type of cytokine that direct the migration (chemotaxis) of white blood cells to infected or damaged tissues. Unlike most other cytokines, chemokines regulate their action through interactions with seven-transmembrane, rhodopsin-like G protein-coupled receptors (GPCRs)[1]. Cytokines are secreted in the mammalian immune system,  and used as messenger molecules to control the duration and strength of the immune response to foreign microorganisms. Many cytokines produced by T cells direct the immune response of various white blood cells (leukocytes) to a foreign microorganism in the body. Among the important varieties are the interleukin (IL) molecules and interferon alpha and beta. The ILs help regulate inflammation, fever, and wound healing, among other things, while the interferons block the replication of viruses[2],[3]. As part of the superfamily of cytokine receptors belongs to the large family of GPCR receptors (GPCR-A1 and A2), among which the CCR and CXC type chemokine receptors, Axon Ligands™ that interact with these receptors have thus been listed in the corresponding sections of the GPCR receptors as well. Additionally, the superfamily of cytokine receptors differentiates tumor necrosis factor (TNF) type receptors and interleukin (IL) type receptors, and a small sub-family of other cytokine receptors that do not fit into the previously lised subfamilies, based on either structure or function.

[1] M.J. Cameron, D.J. Kelvin. Cytokines, Chemokines and Their Receptors. Mdm. Curie Biosc. Dbase [Internet]. Landes Bioscience 2000.
[2] L.C. Borish, J.W. Steinke. 2. Cytokines and chemokines. J. Allergy Clin. Immunol. 2003, 111, S460-75.
[3] C.A. Dinarello. Historical Review of Cytokines. Eur. J. Immunol. 2007, 37, S34-S45.

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Axon ID Name Description From price
3189 4-CPPC First potent, selective and reversible inhibitor of MIF-2 €135.00
1369 Apilimod Cytokine inhibitor; IL-12 and IL-23 inhibitor €110.00
2500 Apilimod dimesylate Cytokine inhibitor; IL-12 and IL-23 inhibitor €110.00
3428 CSF1R inhibitor compound 22 Potent, cellular active and orally bioavailable CSF1R inhibitor €130.00
2887 DRI-C21045 Inhibitor of the CD40-CD40L costimulatory protein-protein interaction €125.00
2800 Ensemble Compound 159 Cytokine inhibitor; IL-17A inhibitor Inquire
2571 GW 2580 Orally bioavailable inhibitor of cFMS kinase and CSF1R €75.00
3949 ISO-1 MIF inhibitor €120.00
1793 Lenalidomide TNFα inhibitor. Immunomodulator. €40.00
2966 NSC745887 DcR3 inhibitor €95.00
2501 Pexidartinib Mutil-targeted RTK inhibitor of CSF1R, c-Kit, and FLT3 €60.00
3054 PLX5622 Potent, specific, orally bioavailable and brain-penetrant inhibitor of CSF1R €80.00
3166 Pomalidomide TNFα inhibitor. Immunomodulator. €60.00
2999 RCGD 423 gp130 signalling modulator €95.00
2324 SC 144 hydrochloride The first-in-class small-molecule gp130 inhibitor €130.00
4084 Sotuletinib Potent, selective and brain-penetrant inhibitor of CSF1R €120.00
2143 SPD 304 Cell permeable inhibitor of TNFα €145.00
3324 Thalidomide TNFα inhibitor. Immunomodulator. €50.00
3410 UTL-5g TNFα modulator €120.00

19 Item(s)

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