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DRI-C21045
Axon 2887
CAS:
2101765-81-3
Purity:
98%
- Soluble in DMSO
- MF: C32H24N2O7S
- MW: 580.61
Description
DRI-C21045 is an inhibitor of the CD40–CD40L costimulatory protein–protein interaction with an IC50 value of 0.17 µM. It prevents CD40L-driven receptor activation and downstream immune signaling.
DRI-C21045 demonstrates low-micromolar cellular activity in NF-κB reporter, THP-1 myeloid, and primary human B cells. Preclinically, it is used in skin-transplant and T-cell expansion models to study pharmacological blockade of adaptive immune costimulation.
Key Features
- CD40–CD40L interaction inhibitor
- Biochemical IC50: 0.17 µM
- Blocks CD40L-induced NF-κB activation
- Active in myeloid and primary B-cell assays
Applications
- CD40 costimulatory signaling
- Protein–protein interaction assays
- NF-κB reporter studies
- B-cell and T-cell activation research
- Transplantation and alloimmune models
More Information
| Parent CAS No. | 2101765-81-3 |
|---|---|
| Chemical Name | 8-(4'-(4-(Methoxycarbonyl)benzamido)biphenyl-4-ylcarboxamido)naphthalene-1-sulfonic acid |
| SMILES | C1C=C(C(=O)NC2C=CC(C3C=CC(C(=O)NC4C5C(S(O)(=O)=O)=CC=CC=5C=CC=4)=CC=3)=CC=2)C=CC=1C(=O)OC |
| MFCD | N.A. |
| InChi | InChI=1S/C32H24N2O7S/c1-41-32(37)25-14-12-23(13-15-25)30(35)33-26-18-16-21(17-19-26)20-8-10-24(11-9-20)31(36)34-27-6-2-4-22-5-3-7-28(29(22)27)42(38,39)40/h2-19H,1H3,(H,33,35)(H,34,36)(H,38,39,40) |
| InChiKey | BZAWLSZPOBGURT-UHFFFAOYSA-N |
| CID | 129275747 |
| Short Description | CD40–CD40L inhibitor |
DRI-C21045
CD40–CD40L interaction inhibitor
DRI C21045
DRIC21045
CD40
Immunomodulation
THP-1
TNF-TNFR
CD40–CD40L interaction
Inhibitor
NF-κB signaling
CD40 costimulatory signaling
Protein–protein interaction assays
NF-κB reporter studies
B-cell and T-cell activation research
Transplantation and alloimmune models
adaptive immunity
T-cell biology
signal transduction
receptor pharmacology
CAS 2101765-81-3
Axon Medchem
Axon 2887
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