gp130
Among cytokine receptors, Glycoprotein 130 (gp130) is the most promiscuous, meaning that it can transduce signals from many different ligands: it is part of the receptor signaling complexes for at least 9 cytokines of the Interleukin (IL)-6 family, a group of functionally and structurally related proteins that utilize gp130 as a common signal transducer within their receptor complex that is required for signaling. Ligand binding induces the association of gp130 with a cytokine-specific receptor-α chain, followed by the activation of downstream signaling cascades including JAK/STAT, RAS/RAF/MAPK, and PI3K/AKT pathways. As a ubiquitously expressed receptor, gp130 is involved in a wide range of important biologic processes including inflammation, immune resonse, cancer, stem cell maintenance, embryonic development, hematopoiesis, cardiovascular action, and neuronal survival[1],[2].
[1] S. Xu et al. Discovery of a novel orally active small-molecule gp130 inhibitor for the treatment of ovarian cancer. Mol Cancer Ther. 2013 Jun;12(6):937-49.
[2] U.A. White et al. The gp130 receptor cytokine family: regulators of adipocyte development and function. Curr Pharm Des. 2011;17(4):340-6.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2999 | RCGD 423 | gp130 signalling modulator | €95.00 | |
2324 | SC 144 hydrochloride | The first-in-class small-molecule gp130 inhibitor | €130.00 |