Among cytokine receptors, Glycoprotein 130 (gp130) is the most promiscuous, meaning that it can transduce signals from many different ligands: it is part of the receptor signaling complexes for at least 9 cytokines of the Interleukin (IL)-6 family, a group of functionally and structurally related proteins that utilize gp130 as a common signal transducer within their receptor complex that is required for signaling. Ligand binding induces the association of gp130 with a cytokine-specific receptor-α chain, followed by the activation of downstream signaling cascades including JAK/STAT, RAS/RAF/MAPK, and PI3K/AKT pathways. As a ubiquitously expressed receptor, gp130 is involved in a wide range of important biologic processes including inflammation, immune resonse, cancer, stem cell maintenance, embryonic development, hematopoiesis, cardiovascular action, and neuronal survival[1],[2].