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Ensemble Compound 159

Axon 2800
CAS:  1449208-36-9
  • Optical Purity:  Optically pure
  • MF:  C42H51ClN6O6
  • MW:  771.34

Description

Ensemble Compound 159 is a macrocyclic peptide inhibitor of the cytokine interleukin-17A (IL-17A) with a reported Kd below 100 nM. It binds IL-17A and blocks the formation of IL-17A–IL-17RA receptor complex.

Validated via ELISA, cell, and in vivo assays, it effectively targets extracellular IL-17A signaling and downstream inflammatory gene expression.

Key Features

  • Peptide inhibitor of IL-17A
  • Kd: below 100 nM by SPR
  • Blocks IL-17A–IL-17RA complex formation
  • Active in biochemical and cell-based cytokine assays

Applications

  • IL-17A cytokine research
  • IL-17A–IL-17RA interaction assays
  • GROα and inflammatory mediator measurements
  • Synovial fibroblast studies
  • Autoimmune and inflammatory disease models

More Information

Parent CAS No. 1449208-36-9
Chemical Name (2S)-3-(2-chlorophenyl)-2-(2-phenylacetamido)-N-(4-(((9R)-7,10,13,21-tetraoxo-8,11,14,20-tetraazaspiro[4.17]docosan-9-yl)methyl)phenyl)propanamide
SMILES C1(CC(=O)N[C@@H](CC2C(Cl)=CC=CC=2)C(=O)NC2C=CC(C[C@H]3NC(=O)CC4(CCCC4)CC(=O)NCCCCCNC(=O)CNC3=O)=CC=2)C=CC=CC=1 |&1:5,22,r|
MFCD N.A.
InChi InChI=1S/C42H51ClN6O6/c43-33-14-6-5-13-31(33)25-35(48-36(50)24-29-11-3-1-4-12-29)41(55)47-32-17-15-30(16-18-32)23-34-40(54)46-28-39(53)45-22-10-2-9-21-44-37(51)26-42(19-7-8-20-42)27-38(52)49-34/h1,3-6,11-18,34-35H,2,7-10,19-28H2,(H,44,51)(H,45,53)(H,46,54)(H,47,55)(H,48,50)(H,49,52)/t34-,35+/m1/s1
InChiKey HSTNEKZTSOZTDI-GPOMZPHUSA-N
CID 117810400
Short Description IL-17A inhibitor

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