CSF1R
Colony-stimulating factor 1 (CSF1) and interleukin-34 (IL-34) are functional ligands of the CSF1 receptor (CSF1R) and thus are key regulators of the monocyte/macrophage lineage. CSF1, also known as M-CSF, regulates the survival, proliferation, differentiation, and chemotaxis of cells of the monocyte/macrophage lineage. It is produced by multiple cell types, including monocytes/macrophages, endothelial cells, fibroblasts, and bone marrow stromal cells. The biological effects of CSF1 are mediated by a single CSF1 receptor (CSF1R), which is encoded by the c-fms proto-oncogene. Ligand binding to CSF1R in macrophages triggers multiple signal transduction pathways resulting in activation of AKT and cAMP responsive element–binding protein (CREB) and mitogen-activated protein kinase[1]. Interestingly, high levels of CSF1 have been implicated in the patophysiology of Alzheimer's disease[2].
[1] J. Luo et al. Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 2013 Jan 14;210(1):157-72.
[2] A. Olmos-Alonso et al. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer's-like pathology. Brain. 2016 Jan 8. pii: awv379.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3428 | CSF1R inhibitor compound 22 | Potent, cellular active and orally bioavailable CSF1R inhibitor | €130.00 | |
| 2571 | GW 2580 | Orally bioavailable inhibitor of cFMS kinase and CSF1R | €75.00 | |
| 2501 | Pexidartinib | Mutil-targeted RTK inhibitor of CSF1R, c-Kit, and FLT3 | €60.00 | |
| 3054 | PLX5622 | Potent, specific, orally bioavailable and brain-penetrant inhibitor of CSF1R | €80.00 | |
| 4084 | Sotuletinib | Potent, selective and brain-penetrant inhibitor of CSF1R | €120.00 | |