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SGI 1776 free base
Axon 1633
CAS:
1025065-69-3
Purity:
98%
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C20H22F3N5O
- MW: 405.42
Description
A potent and selective inhibitor of Pim kinases, inducing apoptosis and cell cycle arrest, thereby causing a reduction in phospho-BAD levels and enhancement of mTOR inhibition in vitro. Most notably, SGI-1776 induced significant tumor regression in MV-4-11 (AML) and MOLM-13 (AML) xenograft models
More Information
| Parent CAS No. | 1025065-69-3 |
|---|---|
| Chemical Name | N-((1-methylpiperidin-4-yl)methyl)-3-(3-(trifluoromethoxy)phenyl)imidazo[1,2-b]pyridazin-6-amine |
| SMILES | C1(NCC2CCN(C)CC2)=NN2C(C3=CC=CC(OC(F)(F)F)=C3)=CN=C2C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26) |
| InChiKey | MHXGEROHKGDZGO-UHFFFAOYSA-N |
| CID | 24795070 |
| Short Description | PIM inhibitor |
References
- LS Chen et al. Pim kinase inhibitor, SGI-1776, induces apoptosis in CLL lymphocytes. Blood, 2009, 114 (19), 4150-4157.
- SM Mumenthaler et al. Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes. Mol. Cancer Ther. 2009, 8(10), 2882-2893.
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