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SMI 4a
- Pim inhibitor 4a
Axon 1923
CAS:
438190-29-5
Purity:
98%
- Soluble in DMSO
- MF: C11H6F3NO2S
- MW: 273.23
Description
ATP-competitive and selective inhibitor of Pim kinases, with IC50 values of 24 and 100 nM for Pim-1 and Pim-2 respectively. SMI-4a inhibits prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines
More Information
| Parent CAS No. | 438190-29-5 |
|---|---|
| Chemical Name | (Z)-5-(3-(trifluoromethyl)benzylidene)thiazolidine-2,4-dione |
| SMILES | C1C=C(/C=C2SC(=O)NC2=O)C=C(C(F)(F)F)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C11H6F3NO2S/c12-11(13,14)7-3-1-2-6(4-7)5-8-9(16)15-10(17)18-8/h1-5H,(H,15,16,17)/b8-5- |
| InChiKey | NGJLOFCOEOHFKQ-YVMONPNESA-N |
| CID | 1361334 |
| Short Description | Pim inhibitor |
References
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