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CX 6258 hydrochloride
Axon 2305
- Parent CAS: 1202916-90-2
Purity:
99%
- Soluble in DMSO
- MF: C26H24ClN3O3.HCl
- MW: 498.4
Description
Potent, selective, and orally efficacious pan-Pim kinases inhibitor (IC50 values 5 nM, 25 nM, and 16 nM for Pim-1, Pim-2, and Pim-3 respectively) with 5-40 fold selectivity over Flt-3 (IC50 values 0.134 μM).CX 6258 exhibited dose dependent efficacy in a mouse MV-4-11 xenograft study, with a 50 mg/kg dose producing 45% tumor growth inhibition (TGI) and a 100 mg/kg dose producing 75% TGI, and was well tolerated throughout the study.
More Information
| Parent CAS No. | 1202916-90-2 |
|---|---|
| Chemical Name | (E)-5-chloro-3-((5-(3-(4-methyl-1,4-diazepane-1-carbonyl)phenyl)furan-2-yl)methylene)indolin-2-one hydrochloride |
| SMILES | N1C2=C(C=C(Cl)C=C2)/C(=CC2=CC=C(C3=CC=CC(C(N4CCCN(C)CC4)=O)=C3)O2)/C1=O.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C26H24ClN3O3.ClH/c1-29-10-3-11-30(13-12-29)26(32)18-5-2-4-17(14-18)24-9-7-20(33-24)16-22-21-15-19(27)6-8-23(21)28-25(22)31;/h2,4-9,14-16H,3,10-13H2,1H3,(H,28,31);1H/b22-16+; |
| InChiKey | YYIMMVXTWBIEAG-YHLMHSEJSA-N |
| CID | 72201040 |
| Short Description | PIM inhibitor |
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