The Src family of protein tyrosine kinases (SFKs; EC plays key roles in regulating signal transduction by a diverse set of cell surface receptors in the context of multiple cellular environments. The nine members of the Src family include Src, Lck, Hck, Fyn, Blk, Lyn, Fgr, Yes, and Yrk, and all share a very similar domain structure with a high degree of homology in the SH1 (catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association) domains. In the auto-inhibited, tail-phosphorylated (Tyr527) state, the SH3 and SH2 domains turn inward and make intramolecular interactions that lock the catalytic domain in an inactive conformation. Several lines of evidence indicate that loss of Tyr527 phosphorylation by protein tyrosine phosphatases (PTPs) leads to activation of Src catalytic activity[1],[2].

SRC-family members listed: SRC, Lck, Lyn

[1] S.M. Thomas, J.S. Brugge. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 1997, 13, 513-609.
[2] M.P. Playford, M.D. Schaller. The interplay between Src and integrins in normal and tumor biology. Oncogene 2004, 23, 7928-7946. 

19 Item(s)

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Axon ID Name Description From price
1892 1-NM-PP1 Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) €95.00
1698 A 770041 Orally active src-family selective lck inhibitor €140.00
1456 AZD0530 difumarate Inhibitor of SRC and ABL tyrosine kinases €70.00
4010 BLK degrader compound 9 First potent and highly selective monomeric degrader of B-lymphoid tyrosine kinase (BLK)  Recently added €180.00
2097 CGP 77675 Src Family kinase (SFK) inhibitor €65.00
1392 Dasatinib Bcr-Abl and Src tyrosine kinase inhibitor €90.00
4079 Insulin sensitizer C59 Insulin sensitizer by targeting Unc119b  Recently added €110.00
3270 Lj-1-60 Fyn inhibitor targeting the Fyn/Stat3 pathway €90.00
1941 MLR 1023 Selective allosteric activator of Lyn kinase €95.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €200.00
2648 Nintedanib RTK inhibitor with antiangiogenic and antineoplastic activities €70.00
3284 Saracatinib Inhibitor of SRC and ABL tyrosine kinases €70.00
1407 SKI 606 Bcr-Abl and Src tyrosine kinase inhibitor €75.00
2778 Squarunkin A Selective UNC119–cargo interaction inhibitor €125.00
2130 Stem Cell Alternative 2i inhibitor Set Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) €110.00
1136 SU 6656 SRC kinase inhibitor €120.00
3099 TL02-59 Potent, selective and orally active Fgr and Lyn inhibitor €120.00
2381 WH-4-023 Orally active src-family selective lck inhibitor €90.00
3973 XL-228 Multitargeted protein kinase inhibitor (IGF1R, Aurora,FGFR, ABL,ALK and SRC) Inquire

19 Item(s)

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