SRC
The Src family of protein tyrosine kinases (SFKs; EC 2.7.10.2) plays key roles in regulating signal transduction by a diverse set of cell surface receptors in the context of multiple cellular environments. The nine members of the Src family include Src, Lck, Hck, Fyn, Blk, Lyn, Fgr, Yes, and Yrk, and all share a very similar domain structure with a high degree of homology in the SH1 (catalytic), linker, SH2 (p-Tyr binding), SH3 (protein-protein interaction) and SH4 (membrane association) domains. In the auto-inhibited, tail-phosphorylated (Tyr527) state, the SH3 and SH2 domains turn inward and make intramolecular interactions that lock the catalytic domain in an inactive conformation. Several lines of evidence indicate that loss of Tyr527 phosphorylation by protein tyrosine phosphatases (PTPs) leads to activation of Src catalytic activity[1],[2].
SRC-family members listed: SRC, Lck, Lyn
[1] S.M. Thomas, J.S. Brugge. Cellular functions regulated by Src family kinases. Annu. Rev. Cell Dev. Biol. 1997, 13, 513-609.
[2] M.P. Playford, M.D. Schaller. The interplay between Src and integrins in normal and tumor biology. Oncogene 2004, 23, 7928-7946.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1892 | 1-NM-PP1 | Potent tyrosine kinase inhibitor (TKI) of multiple targets (Src, Fyn, Abl, CDK, Trk) | €95.00 | |
| 1698 | A 770041 | Orally active src-family selective lck inhibitor | €140.00 | |
| 1456 | AZD0530 difumarate | Inhibitor of SRC and ABL tyrosine kinases | €70.00 | |
| 4010 | BLK degrader compound 9 | First potent and highly selective monomeric degrader of B-lymphoid tyrosine kinase (BLK) | €180.00 | |
| 2097 | CGP 77675 | Src Family kinase (SFK) inhibitor | €65.00 | |
| 1392 | Dasatinib | Bcr-Abl and Src tyrosine kinase inhibitor | €90.00 | |
| 4079 | Insulin sensitizer C59 | Insulin sensitizer by targeting Unc119b | €110.00 | |
| 3270 | Lj-1-60 | Fyn inhibitor targeting the Fyn/Stat3 pathway | €90.00 | |
| 1941 | MLR 1023 | Selective allosteric activator of Lyn kinase | €95.00 | |
| 5011 | Naive Stem Cell 5i inhibitor Set | Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency | €200.00 | |
| 2648 | Nintedanib | RTK inhibitor with antiangiogenic and antineoplastic activities | €70.00 | |
| 3284 | Saracatinib | Inhibitor of SRC and ABL tyrosine kinases | €70.00 | |
| 1407 | SKI 606 | Bcr-Abl and Src tyrosine kinase inhibitor | €75.00 | |
| 2778 | Squarunkin A | Selective UNC119–cargo interaction inhibitor | €125.00 | |
| 2130 | Stem Cell Alternative 2i inhibitor Set | Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386) | €110.00 | |
| 1136 | SU 6656 | SRC kinase inhibitor | €120.00 | |
| 3099 | TL02-59 | Potent, selective and orally active Fgr and Lyn inhibitor | €120.00 | |
| 2381 | WH-4-023 | Orally active src-family selective lck inhibitor | €90.00 | |
| 3973 | XL-228 | Multitargeted protein kinase inhibitor (IGF1R, Aurora,FGFR, ABL,ALK and SRC) | Inquire | |