Kinases (Tyrosine Specific Protein)

Tyrosine specific kinases form a large family of enzymes that are responsible for catalyzing the transfer of ATP to specific tyrosine residues in target proteins. In turn, the phosphorylation of tyrosine residues causes a change in the function of the protein that they are contained in. They function in a variety of processes, signal transduction pathways, and actions, and may be responsible for key events in the body[1]. Axon Ligands™ that interact with tyrosine specific enzymes that are part of the JAK/STAT signaling pathway have been categorized independently. The remainder of Axon Ligands™ that lack interactions with tyrosine kinases of this particular signaling pathway are listed here, grouped on the basis of their selectivity.


[1] Receptor tyrosine kinase signaling: a view from quantitative proteomics. J. Dengjel,I. Kratchmarova, B. Blagoev. Mol. Biosyst. 2009, 5, 1112-1121.

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Axon ID Name Description From price
4153 GS-9973 Selective Syk inhibitor Inquire
3717 GSK2256098 FAK inhibitor Inquire
2121 INNO 406 Dual Bcr-Abl and Lyn kinase inhibitor €85.00
4079 Insulin sensitizer C59 Insulin sensitizer by targeting Unc119b €110.00
1843 JAK2 inhibitor 13 JAK2 inhibitor €110.00
2294 KRCA 0008 Potent and selective dual ALK/ACK1 inhibitor with good drug-like properties €95.00
2862 LFM-A13 Inhibitor of Bruton's tyrosine kinase (BTK) €90.00
3270 Lj-1-60 Fyn inhibitor targeting the Fyn/Stat3 pathway €90.00
2554 LY 2784544 Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F) €95.00
1494 MK 1775 Wee1 kinase inhibitor €80.00
1941 MLR 1023 Selective allosteric activator of Lyn kinase €95.00
1681 Momelotinib JAK1 and JAK2 inhibitor €80.00
4124 Momelotinib hydrochloride JAK1 and JAK2 inhibitor €120.00
3466 MT-802 Potent and rapid degrader of BTK; PROTAC €280.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €200.00
2366 NG 25 trihydrochloride Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) €75.00
2648 Nintedanib RTK inhibitor with antiangiogenic and antineoplastic activities €70.00
2792 NVP-BSK805 Potent, selective and orally bioavailable JAK2 inhibitor €125.00
1416 NVP-TAE684 NPM-ALK inhibitor €50.00
1936 P 505-15 Inhibitor of spleen tyrosine kinase (Syk) €90.00
1858 PCI 32765 Inhibitor of Bruton's tyrosine kinase (BTK) €60.00
3950 Peficitinib Potent and orally bioavailable JAK inhibitor €120.00
2023 PF 03814735 ATP-competitive inhibitor of aurora kinase A and B €120.00
2110 PF 06465469 Inhibitor of interleukin-2 inducible T cell kinase (ITK) €120.00
2107 PF 431396 Dual FAK(PTK2) and PYK2 inhibitor €80.00
1623 PF 573228 FAK inhibitor €95.00
2217 PF 956980 JAK3 inhibitor; analogue of Axon 1338 and 2072 €90.00
4215 PF-562271 Potent, selective, ATP-competitive and reversible dual FAK/PYK2 inhibitor  Recently added €110.00
2459 PND 1186 Orally active dual FAK/PYK2 inhibitor triggering cell apoptosis in tumor cells €90.00
1674 R406 Spleen tyrosine kinase Inhibitor €80.00

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