Kinases (Tyrosine Specific Protein)
Tyrosine specific kinases form a large family of enzymes that are responsible for catalyzing the transfer of ATP to specific tyrosine residues in target proteins. In turn, the phosphorylation of tyrosine residues causes a change in the function of the protein that they are contained in. They function in a variety of processes, signal transduction pathways, and actions, and may be responsible for key events in the body[1]. Axon Ligands™ that interact with tyrosine specific enzymes that are part of the JAK/STAT signaling pathway have been categorized independently. The remainder of Axon Ligands™ that lack interactions with tyrosine kinases of this particular signaling pathway are listed here, grouped on the basis of their selectivity.
[1] Receptor tyrosine kinase signaling: a view from quantitative proteomics. J. Dengjel,I. Kratchmarova, B. Blagoev. Mol. Biosyst. 2009, 5, 1112-1121.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
4153 | GS-9973 | Selective Syk inhibitor | Inquire | |
3717 | GSK2256098 | FAK inhibitor | Inquire | |
2121 | INNO 406 | Dual Bcr-Abl and Lyn kinase inhibitor | €85.00 | |
4079 | Insulin sensitizer C59 | Insulin sensitizer by targeting Unc119b | €110.00 | |
1843 | JAK2 inhibitor 13 | JAK2 inhibitor | €110.00 | |
2294 | KRCA 0008 | Potent and selective dual ALK/ACK1 inhibitor with good drug-like properties | €95.00 | |
2862 | LFM-A13 | Inhibitor of Bruton's tyrosine kinase (BTK) | €90.00 | |
3270 | Lj-1-60 | Fyn inhibitor targeting the Fyn/Stat3 pathway | €90.00 | |
2554 | LY 2784544 | Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F) | €95.00 | |
1494 | MK 1775 | Wee1 kinase inhibitor | €80.00 | |
1941 | MLR 1023 | Selective allosteric activator of Lyn kinase | €95.00 | |
1681 | Momelotinib | JAK1 and JAK2 inhibitor | €80.00 | |
4124 | Momelotinib hydrochloride | JAK1 and JAK2 inhibitor | €120.00 | |
3466 | MT-802 | Potent and rapid degrader of BTK; PROTAC | €280.00 | |
5011 | Naive Stem Cell 5i inhibitor Set | Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency | €200.00 | |
2366 | NG 25 trihydrochloride | Type II inhibitor of TAK1 (MAP3K7) and MAP4K2 (GCK) | €75.00 | |
2648 | Nintedanib | RTK inhibitor with antiangiogenic and antineoplastic activities | €70.00 | |
2792 | NVP-BSK805 | Potent, selective and orally bioavailable JAK2 inhibitor | €125.00 | |
1416 | NVP-TAE684 | NPM-ALK inhibitor | €50.00 | |
1936 | P 505-15 | Inhibitor of spleen tyrosine kinase (Syk) | €90.00 | |
1858 | PCI 32765 | Inhibitor of Bruton's tyrosine kinase (BTK) | €60.00 | |
3950 | Peficitinib | Potent and orally bioavailable JAK inhibitor | €120.00 | |
2023 | PF 03814735 | ATP-competitive inhibitor of aurora kinase A and B | €120.00 | |
2110 | PF 06465469 | Inhibitor of interleukin-2 inducible T cell kinase (ITK) | €120.00 | |
2107 | PF 431396 | Dual FAK(PTK2) and PYK2 inhibitor | €80.00 | |
1623 | PF 573228 | FAK inhibitor | €95.00 | |
2217 | PF 956980 | JAK3 inhibitor; analogue of Axon 1338 and 2072 | €90.00 | |
4215 | PF-562271 | Potent, selective, ATP-competitive and reversible dual FAK/PYK2 inhibitor | €110.00 | |
2459 | PND 1186 | Orally active dual FAK/PYK2 inhibitor triggering cell apoptosis in tumor cells | €90.00 | |
1674 | R406 | Spleen tyrosine kinase Inhibitor | €80.00 |