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PF 573228
Axon 1623
CAS:
869288-64-2
Purity:
99%
- Soluble in DMSO
- MF: C22H20F3N5O3S
- MW: 491.49
Description
Potent and selective inhibitor of focal adhesion kinase (FAK) with IC50 of 4 nM; Displays 50-250-fold selectivity over other protein kinases; a useful tool in functional study of non-receptor tyrosine inhibitor FAK in integrin-dependent signaling pathways in normal and cancer cells
More Information
| Parent CAS No. | 869288-64-2 |
|---|---|
| Chemical Name | 6-(4-(3-(methylsulfonyl)benzylamino)-5-(trifluoromethyl)pyrimidin-2-ylamino)-3,4-dihydroquinolin-2(1H)-one |
| SMILES | C1C=C2NC(=O)CCC2=CC=1NC1N=C(NCC2C=CC=C(S(C)(=O)=O)C=2)C(C(F)(F)F)=CN=1 |
| MFCD | MFCD11519967 |
| InChi | InChI=1S/C22H20F3N5O3S/c1-34(32,33)16-4-2-3-13(9-16)11-26-20-17(22(23,24)25)12-27-21(30-20)28-15-6-7-18-14(10-15)5-8-19(31)29-18/h2-4,6-7,9-10,12H,5,8,11H2,1H3,(H,29,31)(H2,26,27,28,30) |
| InChiKey | HESLKTSGTIBHJU-UHFFFAOYSA-N |
| CID | 11612883 |
| Short Description | FAK inhibitor |
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