CEP-37440 hydrochloride
- Parent CAS: 1391712-60-9
- Optical Purity: 99% e.e.
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C30H38ClN7O3.HCl
- MW: 616.58
Description
CEP-37440 is a highly potent, selective and orally active inhibitor of ALK (Ezymatic IC50: 3.5 nM , Cellular IC50: 40 nM , Cellular IC50 in 75% human plasma: 120 nM) and FAK (Ezymatic IC50: 2.3 nM , Cellular IC50: 88 nM ), displaying a favorable pharmaceutical and pharmacokinetic profile and robust and selective pharmacologic efficacy against ALK /FAK mediated human cancer cells and tumor xenograft models in mice.
More Information
| Parent CAS No. | 1391712-60-9 |
|---|---|
| Chemical Name | (S)-2-(5-Chloro-2-(6-(4-(2-hydroxyethyl)piperazin-1-yl)-1-methoxy-6,7,8,9-tetrahydro-5H-benzo[7]annulen-2-ylamino)pyrimidin-4-ylamino)-N-methylbenzamide hydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C12C[C@@H](N3CCN(CCO)CC3)CCCC=1C(OC)=C(NC1N=CC(Cl)=C(NC3C=CC=CC=3C(=O)NC)N=1)C=C2.Cl |&1:2,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C30H38ClN7O3.ClH/c1-32-29(40)23-7-3-4-9-25(23)34-28-24(31)19-33-30(36-28)35-26-11-10-20-18-21(6-5-8-22(20)27(26)41-2)38-14-12-37(13-15-38)16-17-39;/h3-4,7,9-11,19,21,39H,5-6,8,12-18H2,1-2H3,(H,32,40)(H2,33,34,35,36);1H/t21-;/m0./s1 |
| InChiKey | PYVZBSZLHXGYNL-BOXHHOBZSA-N |
| CID | 169488016 |
| Short Description | ALK and FAK inhibitor |
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