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YH-306
- Soluble in DMSO and EtOH
- MF: C19H18N2O2
- MW: 306.36
Description
YH-306 blocks the activation of FAK and FAK-related signaling pathways, leading to the suppression of CRC growth and metastasis. In vitro, YH-306 significantly inhibited CRC cell migration, invasion, proliferation and colonization, and induced CRC cell apoptosis. In vivo, YH-306 depressed CRC growth and suppressed hepatic/pulmonary metastasis.
More Information
| Parent CAS No. | 1373764-75-0 |
|---|---|
| Chemical Name | 1-(3,4-Dihydro-1H-pyrido[3,4-b]indol-2(9H)-yl)-2-(4-hydroxyphenyl)ethanone |
| SMILES | C12NC3C=CC=CC=3C=1CCN(C(=O)CC1C=CC(O)=CC=1)C2 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H18N2O2/c22-14-7-5-13(6-8-14)11-19(23)21-10-9-16-15-3-1-2-4-17(15)20-18(16)12-21/h1-8,20,22H,9-12H2 |
| InChiKey | WFTJZQLEQGPZBC-UHFFFAOYSA-N |
| CID | 60162063 |
| Short Description | FAK inhibitor |
References
- F Dai et al. A novel synthetic small molecule YH-306 suppresses colorectal tumour growth and metastasis via FAK pathway. J Cell Mol Med. 2015 Feb;19(2):383-95.
- C Zheng et al. Synthesis and biological evaluation of novel tetrahydro-β-carboline derivatives as antitumor growth and metastasis agents through inhibiting the transforming growth factor-β signaling pathway. J Med Chem. 2014 Feb 13;57(3):600-12.
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