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Abivertinib
- AC 0010 - Avitinib
- Soluble in DMSO
- MF: C26H26FN7O2
- MW: 487.53
Description
Abivertinib is a potent, selective, orally available and irreversible third-generation EGFR inhibitor with an IC50 value of 0.18 nM against EGFR L858R/T790M double mutations.
More Information
| Parent CAS No. | 1557267-42-1 |
|---|---|
| Chemical Name | N-(3-(2-(3-Fluoro-4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yloxy)phenyl)acrylamide |
| SMILES | C1(N2CCN(C)CC2)C=CC(NC2N=C(OC3C=CC=C(NC(=O)C=C)C=3)C3C=CNC=3N=2)=CC=1F |
| MFCD | N.A. |
| InChi | InChI=1S/C26H26FN7O2/c1-3-23(35)29-17-5-4-6-19(15-17)36-25-20-9-10-28-24(20)31-26(32-25)30-18-7-8-22(21(27)16-18)34-13-11-33(2)12-14-34/h3-10,15-16H,1,11-14H2,2H3,(H,29,35)(H2,28,30,31,32) |
| InChiKey | UOFYSRZSLXWIQB-UHFFFAOYSA-N |
| CID | 72734520 |
| Short Description | EGFR inhibitor |
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