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LY 2228820
- Ralimetinib
- Soluble in DMSO
- MF: C24H29FN6
- MW: 420.53
Description
LY 2228820 (Ralimetinib) is a potent p38 MAPK inhibitor with reported IC50 values of 7 nM for p38α and 3 nM for p38β.
p38 MAPKs regulate inflammatory cytokine signaling, stress responses and tumor microenvironment interactions. LY 2228820 has been used in oncology research, including studies evaluating enhancement of bortezomib cytotoxicity in multiple myeloma models.
Key Features
- Potent p38α/β MAPK inhibitor
- IC50: 7 nM for p38α and 3 nM for p38β
- Modulates inflammatory and stress-activated kinase signaling
- Relevant to multiple myeloma and combination-treatment research
Applications
- p38 MAPK pathway studies
- Inflammatory cytokine and stress-response assays
- Multiple myeloma model research
- Combination studies with proteasome inhibitors
More Information
| Parent CAS No. | 862505-00-8 |
|---|---|
| Chemical Name | 5-(2-tert-butyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-3-neopentyl-3H-imidazo[4,5-b]pyridin-2-amine |
| SMILES | C12N(CC(C)(C)C)C(N)=NC1=CC=C(C1NC(C(C)(C)C)=NC=1C1=CC=C(F)C=C1)N=2 |
| MFCD | MFCD17169991 |
| InChi | InChI=1S/C24H29FN6/c1-23(2,3)13-31-20-17(28-22(31)26)12-11-16(27-20)19-18(14-7-9-15(25)10-8-14)29-21(30-19)24(4,5)6/h7-12H,13H2,1-6H3,(H2,26,28)(H,29,30) |
| InChiKey | XPPBBJCBDOEXDN-UHFFFAOYSA-N |
| CID | 11539025 |
| Short Description | p38 MAPK inhibitor |
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