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AZD8330
- Soluble in DMSO
- MF: C16H17FIN3O4
- MW: 461.23
Description
AZD8330 is a potent, highly specific non-ATP-competitive MEK inhibitor. It inhibits MEK/MAP2K signaling and thereby suppresses growth factor-mediated ERK pathway activation and tumor cell proliferation.
MEK1/2 are central kinases in the RAF-MEK-ERK cascade downstream of RAS and RAF. AZD8330 is useful for studying MAPK pathway inhibition in oncology models and for probing ERK-dependent proliferation and survival signaling.
Key Features
- Non-ATP-competitive MEK inhibitor
- Blocks RAF-MEK-ERK pathway signaling
- Suppresses growth factor-mediated proliferation signals
- Relevant to MAPK-driven cancer models
Applications
- MEK/ERK signaling studies
- MAPK pathway inhibitor profiling
- Cancer cell proliferation assays
- RAS/RAF pathway pharmacology
More Information
| Parent CAS No. | 869357-68-6 |
|---|---|
| Chemical Name | 2-(2-fluoro-4-iodophenylamino)-N-(2-hydroxyethoxy)-1,5-dimethyl-6-oxo-1,6-dihydropyridine-3-carboxamide |
| SMILES | C1(NC2=CC=C(I)C=C2F)N(C)C(=O)C(C)=CC=1C(NOCCO)=O |
| MFCD | MFCD18384989 |
| InChi | InChI=1S/C16H17FIN3O4/c1-9-7-11(15(23)20-25-6-5-22)14(21(2)16(9)24)19-13-4-3-10(18)8-12(13)17/h3-4,7-8,19,22H,5-6H2,1-2H3,(H,20,23) |
| InChiKey | RWEVIPRMPFNTLO-UHFFFAOYSA-N |
| CID | 16666708 |
| Short Description | MEK1 inhibitor |
References
- JI Trujillo. MEK inhibitors: a patent review 2008-2010. Exp. Opin. Ther. Patents. 2011, 21(7), 1045-1069.
- MS Chapman & JN Miner. Novel mitogen-activated protein kinase kinase inhibitors. Exp. Opin. Invest. Drugs. 2011, 20(2), 209-220.
- C Frémin and S Meloche. From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J. Hematol. Oncol. 2010, 3, 8.
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