Kinases (Dual Specificity)

Protein kinases fall into three broad classes, characterised with respect to substrate specificity: Serine/threonine-protein kinases, Tyrosine-protein kinases, and Dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins)[1].


[1] S.K. Hanks et al. The protein kinase family: conserved features and deduced phylogeny of the catalytic domains. Science. 1988, 241, 42-52.

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Axon ID Name Description From price
4217 AS-703026 Potent, selective and orally bioavailable small molecular inhibitor of MEK1/2  Recently added Inquire
1642 AZ 3146 MPS1 kinase inhibitor €80.00
1516 AZD6244 MEK1 and MEK2 inhibitor €60.00
1999 AZD8330 MEK 1 inhibitor €105.00
3697 Binimetinib Potent, selective, non-ATP-competitive and orally available allosteric inhibitor of MEK1/2 €60.00
1809 BIX 02189 MEK5 inhibitor; ERK5 inhibitor €110.00
3346 BIX02188 Potent MEK5 inhibitor €110.00
1808 BIX02188-Me MEK5 inhibitor; ERK5 inhibitor €110.00
3934 CC-671 Potent and selective dual inhibitor of TTK Inquire
2202 CK2 inhibitor 10 Potent and ATP-competitive inhibitor of CK2 €105.00
2992 CTx-0294885 Broad-spectrum kinase inhibitor €90.00
4056 DYRK1A inhibitor compound 11 Highly selective and ligand-efficient Dyrk1A inhibitor €150.00
4148 GDC-0973 Orally bioavailable, potent and selective small-molecule inhibitor of mitogen-activated protein kinase 1 Inquire
1761 GSK 1120212 MEK1 and MEK2 inhibitor €70.00
2970 GSK626616 Potent, orally bioavailable inhibitor of DYRK3 €120.00
3059 GW 284543 hydrochloride Selective MEK5 inhibitor €95.00
3627 Harmine Potent, selective and ATP-competitive DYRK1A inhibitor €50.00
3538 INDY Potent, selective and ATP-competitive inhibitor of Dyrk1A €110.00
2358 Mps1-IN-2 Inhibitor of Mps1 kinase with add-on affinity for Gak and Plk1 €95.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €200.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €230.00
1408 PD0325901 MEK1 and MEK2 inhibitor €50.00
1368 PD184352 MEK 1 inhibitor €80.00
1223 PD98059 MEK inhibitor €80.00
3540 ProINDY Prodrug of INDY; Dyrk1A inhibitor €110.00
3874 RDEA119 Potent and highly selective small molecule allosteric MEK inhibitor Inquire
1629 Reversine MPS1 kinase inhibitor €85.00
1122 SL 327 MEK1 and MEK2 inhibitor €80.00
2128 Stem Cell 2i inhibitor Set Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386) €90.00
2129 Stem Cell 3i inhibitor Set Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386) €130.00

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