Bulk Inquiry
Reversine
- Soluble in DMSO
- MF: C21H27N7O
- MW: 393.49
Description
Reversine induces differentiated myogenic-lineage committed cells to become multipotent mesenchymal progenitor cells; it is a potent mitotic inhibitor of MPS1 kinase, which inhibits the spindle assembly checkpoint in a dose-dependent manner; also acts as A3 adenosine receptor antagonist (Ki: 660 nM) or aurora kinases inhibitor (IC50: 400-500 nM for Aurora A/B/C respectively).
More Information
| Parent CAS No. | 656820-32-5 |
|---|---|
| Chemical Name | N6-cyclohexyl-N2-(4-morpholinophenyl)-9H-purine-2,6-diamine |
| SMILES | N(C1CCCCC1)C1N=C(NC2C=CC(N3CCOCC3)=CC=2)N=C2NC=NC=12 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27) |
| InChiKey | ZFLJHSQHILSNCM-UHFFFAOYSA-N |
| CID | 210332 |
| Short Description | MPS1 inhibitor |
References
- M Saraiya et al. Reversine Enhances Generation of Progenitor-like Cells by Dedifferentiation of Annulus Fibrosus Cells. Tissue Eng. Part A. 2010, 16(4), 1443–1455.
- S Santaguida etal. Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine. J. Cell Biol. 2010, 190(1), 73-87.
- AM D'Alise et al. Reversine, a novel Aurora kinases inhibitor, inhibits colony formation of human acute myeloid leukemia cells. Mol. Cancer Ther. 2008, 7(5), 1140-1149.
- L Anastasia et al. Reversine-treated fibroblasts acquire myogenic competence in vitro and in regenerating skeletal muscle. Cell Death and Differentiation 2006, 13, 2042–2051.
- S Chen et al. Dedifferentiation of lineage-committed cells by a small molecule. J. Am. Chem. Soc. 2004, 126, 410-411.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1642 | AZ 3146 |
From $88.00 |
| 1701 | Shz-1 |
From $104.50 |
| 2165 | S 12 |
From $115.50 |
| 2320 | FH 1 |
From $55.00 |
| 2322 | Neuropathiazol |
From $143.00 |
| 2355 | FPH 2 |
From $121.00 |
| 2358 | Mps1-IN-2 |
From $104.50 |
| 2439 | Dimethylenastron |
From $115.50 |
| 2446 | Ispinesib |
From $121.00 |
| 2474 | SPL-B |
From $137.50 |
| 2550 | Cardiogenol C hydrochloride |
From $99.00 |
| 2755 | TC Mps1 12 |
From $126.50 |
| 3934 | CC-671 |
From Inquiry |
