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Cardiogenol C hydrochloride
Axon 2550
- Parent CAS: 671225-39-1
Purity:
99%
- Soluble in water and DMSO
- MF: C13H16N4O2.HCl
- MW: 296.75
Description
Cardiogenol C hydrochloride is a small-molecule inducer of embryonic stem-cell differentiation toward cardiomyocytes. It promotes myosin heavy chain-positive cardiomyocyte formation in ESC-derived systems.
Cardiomyocyte differentiation requires coordinated regulation of developmental transcription, sarcomeric protein expression and cardiac lineage commitment. Cardiogenol C hydrochloride is useful for cardiac differentiation protocols and regenerative medicine pathway studies.
Key Features
- Cardiomyocyte differentiation inducer
- Reported EC50: 0.1 µM for induction of MHC-positive cardiomyocytes from ESCs
- Promotes cardiac lineage commitment in stem-cell models
- Useful for regenerative and developmental biology assays
Applications
- Stem-cell cardiomyocyte differentiation
- Cardiac development pathway research
- Regenerative medicine assay development
- Myosin heavy chain and lineage-marker studies
More Information
| Parent CAS No. | 671225-39-1 |
|---|---|
| Chemical Name | 2-(2-(4-methoxyphenylamino)pyrimidin-4-ylamino)ethanol hydrochloride |
| SMILES | C(O)CNC1C=CN=C(NC2=CC=C(OC)C=C2)N=1.Cl |
| MFCD | MFCD06798334 |
| InChi | InChI=1S/C13H16N4O2.ClH/c1-19-11-4-2-10(3-5-11)16-13-15-7-6-12(17-13)14-8-9-18;/h2-7,18H,8-9H2,1H3,(H2,14,15,16,17);1H |
| InChiKey | QQAHYSZVJLHCNA-UHFFFAOYSA-N |
| CID | 11345983 |
| Short Description | Stem cell differentiator |
Cardiogenol C hydrochloride
inducer of embryonic stem-cell differentiation toward cardiomyocytes
Cardiogenol C
Stem cell differentiator
ESCs
Stem-cell cardiomyocyte differentiation
Cardiac development pathway research
Regenerative medicine assay development
Myosin heavy chain and lineage-marker studies
cell differentiation
regenerative medicine
cardiovascular research
transcriptional regulation
developmental biology
ESC
CAS 671225-39-1
CAS 1049741-55-0
Axon Medchem
Axon 2550
Supplier
Vendor
References
- X Wu et al. Small molecules that induce cardiomyogenesis in embryonic stem cells. J Am Chem Soc. 2004 Feb 18;126(6):1590-1.
- AK Mike et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33(1):205-21.
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