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TC Mps1 12
Axon 2755
CAS:
1206170-62-8
Purity:
99%
- Soluble in DMSO
- MF: C17H20N6O
- MW: 324.38
Description
TC Mps1 12 is a potent and selective inhibitor of the mitotic checkpoint kinase MPS1/TTK with an IC50 value of 6.4 nM. By blocking MPS1, it weakens spindle-assembly checkpoint signaling, allowing premature mitotic progression and increasing chromosome-segregation errors.
TC Mps1 12 shows cellular activity, suitable pharmacokinetic properties and efficacy in A549 xenograft studies. It has also been used to induce chromosomal instability and suppress growth of hepatocellular carcinoma cells, making it useful for mitosis, aneuploidy and checkpoint-dependency research.
Key Features
- Potent MPS1 inhibitor (IC50 = 6.4 nM)
- Disrupts the spindle-assembly checkpoint
- Promotes chromosomal instability
- Bioactive in xenograft models
Applications
- MPS1/TTK kinase research
- Spindle-checkpoint assays
- Mitosis and chromosome-segregation studies
- Aneuploidy research
- Cancer-cell and xenograft models
More Information
| Parent CAS No. | 1206170-62-8 |
|---|---|
| Chemical Name | 4-(4-Amino-6-(tert-butylamino)-5-cyanopyridin-2-ylamino)benzamide |
| SMILES | C1(C(=O)N)C=CC(NC2C=C(N)C(C#N)=C(NC(C)(C)C)N=2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C17H20N6O/c1-17(2,3)23-16-12(9-18)13(19)8-14(22-16)21-11-6-4-10(5-7-11)15(20)24/h4-8H,1-3H3,(H2,20,24)(H4,19,21,22,23) |
| InChiKey | XDEFNAWAKYQBQY-UHFFFAOYSA-N |
| CID | 70682875 |
| Short Description | Mps1 inhibitor |
TC Mps1 12
MPS1/TTK inhibitor
MPS1/TTK
MPS1 Kinase
Inhibitor
MPS1/TTK kinase research
Spindle-checkpoint assays
Mitosis and chromosome-segregation studies
Aneuploidy research
Cancer-cell and xenograft models
cell cycle
liver cancer
pharmacokinetics
kinase signaling
receptor selectivity
signal transduction
CAS 1206170-62-8
Axon Medchem
Axon 2755
Supplier
Vendor
References
- K Ken-ichi et al. Diaminopyridine-Based Potent and Selective Mps1 Kinase Inhibitors Binding to an Unusual Flipped-Peptide Conformation. ACS Med Chem Lett. 2012 Jul 12; 3(7): 560–564.
- M Choi et al. TC Mps1 12, a novel Mps1 inhibitor, suppresses the growth of hepatocellular carcinoma cells via the accumulation of chromosomal instability. Br J Pharmacol. 2017 Jun;174(12):1810-1825.
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