MPS1 (EC 188.8.131.52), a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. Deregulation of these processes or uncoupling of its component parts can lead to aneuploidy and chromosomal instability (CIN), which are recognized hallmarks of cancer.
 Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. N. Kwiatkowski et al. Nat. Chem. Biol. 2010, 6, 359–368.