MPS1 Kinase

MPS1 (EC 2.7.12.1), a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. Deregulation of these processes or uncoupling of its component parts can lead to aneuploidy and chromosomal instability (CIN), which are recognized hallmarks of cancer[1].


[1] Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. N. Kwiatkowski et al. Nat. Chem. Biol. 2010, 6, 359–368.

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Axon ID Name Description From price
1642 AZ 3146 MPS1 kinase inhibitor €90.00
2358 Mps1-IN-2 Inhibitor of Mps1 kinase with add-on affinity for Gak and Plk1 €95.00
1629 Reversine MPS1 kinase inhibitor €95.00

3 Item(s)

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