MPS1 Kinase
MPS1 (EC 2.7.12.1), a dual-specificity kinase, is required for the proper functioning of the spindle assembly checkpoint and for the maintenance of chromosomal stability. Deregulation of these processes or uncoupling of its component parts can lead to aneuploidy and chromosomal instability (CIN), which are recognized hallmarks of cancer[1].
[1] Small-molecule kinase inhibitors provide insight into Mps1 cell cycle function. N. Kwiatkowski et al. Nat. Chem. Biol. 2010, 6, 359–368.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1642 | AZ 3146 | MPS1 kinase inhibitor | €80.00 | |
| 3934 | CC-671 | Potent and selective dual inhibitor of TTK | Inquire | |
| 2358 | Mps1-IN-2 | Inhibitor of Mps1 kinase with add-on affinity for Gak and Plk1 | €95.00 | |
| 1629 | Reversine | MPS1 kinase inhibitor | €85.00 | |
| 2755 | TC Mps1 12 | Potent and selective inhibitor of MPS1 kinase | €115.00 | |