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SR-318
- Soluble in DMSO
- MF: C27H33N5O2
- MW: 459.58
Description
SR-318 is a highly potent and selective type-II p38 α/β inhibitor with IC50 values of 3.7 and 10 nM for p38α and p38β, respectively. SR-318 also potently inhibited the TNF-α release in whole blood.
More Information
| Parent CAS No. | 2413286-32-3 |
|---|---|
| Chemical Name | 5-Amino-N-(4-(3-cyclohexylpropylcarbamoyl)benzyl)-1-phenyl-1H-pyrazole-4-carboxamide |
| SMILES | C1(CNC(=O)C2C=NN(C3C=CC=CC=3)C=2N)C=CC(C(=O)NCCCC2CCCCC2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C27H33N5O2/c28-25-24(19-31-32(25)23-11-5-2-6-12-23)27(34)30-18-21-13-15-22(16-14-21)26(33)29-17-7-10-20-8-3-1-4-9-20/h2,5-6,11-16,19-20H,1,3-4,7-10,17-18,28H2,(H,29,33)(H,30,34) |
| InChiKey | HXNUFFCHRIWTRZ-UHFFFAOYSA-N |
| CID | 139030333 |
| Short Description | p38 MAPK inhibitor |
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