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MK2 inhibitor III
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H16N4O
- MW: 340.38
Description
MK2 inhibitor III is a potent and selective inhibitor of MK-2 with an IC50 value of 8.5 nM. MK2 inhibitor III was found to be effective in reducing TNF-α production in both U937 cells and in vivo.
More Information
| Parent CAS No. | 724711-21-1 |
|---|---|
| Chemical Name | 2-(2-(Quinolin-3-yl)pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-one |
| SMILES | C1(C2C=NC3C=CC=CC=3C=2)C=C(C2NC3CCNC(=O)C=3C=2)C=CN=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H16N4O/c26-21-16-11-20(25-18(16)6-8-23-21)14-5-7-22-19(10-14)15-9-13-3-1-2-4-17(13)24-12-15/h1-5,7,9-12,25H,6,8H2,(H,23,26) |
| InChiKey | OWFLADWRSCINST-UHFFFAOYSA-N |
| CID | 10389239 |
| Short Description | MK-2 inhibitor |
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