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Mitochonic acid 5
- MA-5
- Soluble in 0.1N NaOH(aq) and DMSO
- MF: C18H13F2NO3
- MW: 329.3
Description
Mitochonic acid 5 (MA-5) is a mitochondrial drug. MA-5 acts via the MAPK-ERK-Yap signaling pathway, which increases Bnip3-related mitophagy, leading to suppressed apoptotic signaling following the inflammatory response. MA-5 can protect mitochondrial function by regulating energy metabolism and reducing mitochondrial oxidative stress. Mitochonic acid 5 increased ATP, rescued mitochondrial disease fibroblasts and prolonged the life span of the disease model “Mitomouse”.
More Information
| Parent CAS No. | 1354707-41-7 |
|---|---|
| Chemical Name | 4-(2,4-Difluorophenyl)-2-(1H-indol-3-yl)-4-oxobutanoic acid |
| SMILES | C1C(F)=CC(F)=C(C(=O)CC(C(=O)O)C2=CNC3C=CC=CC2=3)C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H13F2NO3/c19-10-5-6-12(15(20)7-10)17(22)8-13(18(23)24)14-9-21-16-4-2-1-3-11(14)16/h1-7,9,13,21H,8H2,(H,23,24) |
| InChiKey | BOKQALWNGNLTOC-UHFFFAOYSA-N |
| CID | 154827477 |
| Short Description | Mitochondrial drug |
References
- T Suzuki et al. Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts From Patients With Mitochondrial Diseases Tohoku J Exp Med 2015 Jul;236(3):225-32
- T Matsuhashi et al. Mitochonic Acid 5 (MA-5) Facilitates ATP Synthase Oligomerization and Cell Survival in Various Mitochondrial Diseases. EBioMedicine. 2017;20:27-38.
- Q Lei et al. Mitochonic acid 5 activates the MAPK-ERK-yap signaling pathways to protect mouse microglial BV-2 cells against TNFα-induced apoptosis via increased Bnip3-related mitophagy. Cell Mol Biol Lett. 2018;23:14.
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