Ulixertinib hydrochloride
- BVD-523 hydrochloride - VRT752271 hydrochloride
- Parent CAS: 869886-67-9
- Optical Purity: >99% e.e.
- Soluble in DMSO
- MF: C21H23Cl3N4O2
- MW: 469.79
Description
Birinapant is a cell permeable, orally bioavailable, synthetic bivalent small molecule peptido mimetics of second mitochondrial-derived activator of caspases (SMAC) and potent and selective inhibitor of IAP (Inhibitor of Apoptosis Protein) family proteins with Kd values of 45 nM and <1 nM for XIAP and cIAP1, respectively. SMAC mimetics Birinapant and LCL-161 (Axon 3902) are also negative regulators of HIV-1 transcription, promoting reversal of viral latency.
More Information
| Parent CAS No. | 869886-67-9 |
|---|---|
| Chemical Name | (S)-4-(5-chloro-2-iisopropylamino)pyridin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide hydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1([C@@H](CO)NC(=O)C2=CC(C3C(Cl)=CN=C(NC(C)C)C=3)=CN2)C=C(Cl)C=CC=1.Cl |&1:1,r| |
| MFCD | N.A. |
| InChi | N.A. |
| InChiKey | N.A. |
| CID | N.A. |
| Short Description | ERK1/2 kinases |
References
- C Ning, et al. Targeting ERK Enhances the Cytotoxic Effect of the Novel PI3K and mTOR Dual Inhibitor VS-5584 in Preclinical Models of Pancreatic Cancer. Oncotarget. 2017 Jul 4;8(27):44295-44311.
- RA Ward et al. Structure-Guided Design of Highly Selective and Potent Covalent Inhibitors of ERK1/2. J Med Chem. 2015 Jun 11;58(11):4790-801.
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