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EI-52
Axon 4284
CAS:
2215927-89-0
Purity:
99%
- Soluble in DMSO and EtOH
- MF: C22H21N5O2
- MW: 387.44
Description
EI-52 is an inhibitor of ERK-MYD88 interaction with IC50 values of 3.1 and 14.7 µM for MYD88/ERK1 and MYD88/ERK2 interaction inhibition by HTRF, respectively. ERK-MYD88 interaction inhibition induces an HRI-mediated integrated stress response (ISR), resulting in immunogenic apoptosis specific to cancer cells.
More Information
| Parent CAS No. | 2215927-89-0 |
|---|---|
| Chemical Name | N-(6-Methoxy-3-pyridyl)-2-(4-(dimethylamino)phenyl)-1H-1,3-benzimidazole-5-carboxamide |
| SMILES | C1=CC(NC(C2=CC3N=C(C4=CC=C(N(C)C)C=C4)NC=3C=C2)=O)=CN=C1OC |
| MFCD | N.A. |
| InChi | InChI=1S/C22H21N5O2/c1-27(2)17-8-4-14(5-9-17)21-25-18-10-6-15(12-19(18)26-21)22(28)24-16-7-11-20(29-3)23-13-16/h4-13H,1-3H3,(H,24,28)(H,25,26) |
| InChiKey | KNOQKFKILLZESZ-UHFFFAOYSA-N |
| CID | 134373088 |
| Short Description | ERK-MYD88 inhibitor |
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