VX-11e
- ERK11e
- Optical Purity: >99% e.e.
- Soluble in DMSO
- MF: C24H20Cl2FN5O2
- MW: 500.35
Description
Extracellular signal regulated kinase (ERK) is a pivotal enzyme in the pathway downstream of Ras, Raf, and MEK, acting as a central link between multiple signaling pathways. VX-11e (or ERK 11e) is a potent, selective, and orally bioavailable inhibitor of ERK2 with Ki < 2 nM, exhibiting potent cellular activity (IC50=48 nM in an HT29 cell proliferation assay). It is highly selective against a panel of more than 140 other kinases - most notably, GSK3 (Ki = 400nM), AURA (Ki = 540nM), CDK2 (Ki = 850nM), FLT3 (Ki = 1400nM), ROCK1 (Ki = 1400nM), and JNK3 (Ki = 1400nM).
More Information
| Parent CAS No. | 896720-20-0 |
|---|---|
| Chemical Name | (S)-4-(2-(2-chloro-4-fluorophenylamino)-5-methylpyrimidin-4-yl)-N-(1-(3-chlorophenyl)-2-hydroxyethyl)-1H-pyrrole-2-carboxamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | N1C(NC2C=CC(F)=CC=2Cl)=NC(C2C=C(C(=O)N[C@@H](C3C=C(Cl)C=CC=3)CO)NC=2)=C(C)C=1 |&1:19,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C24H20Cl2FN5O2/c1-13-10-29-24(31-19-6-5-17(27)9-18(19)26)32-22(13)15-8-20(28-11-15)23(34)30-21(12-33)14-3-2-4-16(25)7-14/h2-11,21,28,33H,12H2,1H3,(H,30,34)(H,29,31,32)/t21-/m1/s1 |
| InChiKey | WUTVMXLIGHTZJC-OAQYLSRUSA-N |
| CID | 11634725 |
| Short Description | ERK2 inhibitor |
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