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SB 203580
- Soluble in 0.1N HCl(aq) and DMSO
- MF: C21H16FN3OS
- MW: 377.43
Description
SB 203580 is a potent, cell-permeable and selective p38 mitogen-activated protein kinase (p38 MAPK) inhibitor. SB 203580 is one of the most widely cited p38 inhibitors and has been extensively used to investigate the role of p38 signaling in inflammation, stress responses, differentiation, and disease biology.
The p38 MAPK pathway is activated by inflammatory cytokines, cellular stress, and environmental stimuli, regulating cytokine production, apoptosis, proliferation, and differentiation. SB 203580 has been widely used in inflammation research due to its ability to suppress p38-dependent signaling and downstream production of pro-inflammatory mediators. In addition, p38 inhibition has important applications in stem cell biology, where modulation of p38 signaling can influence pluripotency, self-renewal, differentiation, and cellular reprogramming. SB 203580 remains a valuable tool for studying MAPK signaling, inflammatory responses, developmental biology, and regenerative medicine.
Key Features
- Potent and selective p38 MAPK inhibitor
- Cell-permeable small molecule inhibitor
- Widely used tool for p38 signaling research
- Suppresses inflammatory signaling pathways
- Useful in stem cell and developmental biology studies
Applications
- p38 MAPK signaling research
- Inflammation and cytokine signaling studies
- Stem cell differentiation and pluripotency research
- Cellular stress response investigations
- Developmental biology and regenerative medicine studies
Related Products
For applications requiring improved aqueous solubility, SB 203580 hydrochloride (Axon 1465) is available as the water-soluble form of SB 203580. Researchers interested in more advanced p38 inhibition may also consider BIRB 796 (Axon 1358), a highly potent inhibitor of all four p38 MAPK isoforms.
More Information
| Parent CAS No. | 152121-47-6 |
|---|---|
| Chemical Name | 4-[5-(4-Fluoro-phenyl)-2-(4-methanesulfinyl-phenyl)-3H-imidazol-4-yl]-pyridine |
| SMILES | N1C=CC(C2NC(C3C=CC(S(=O)C)=CC=3)=NC=2C2C=CC(F)=CC=2)=CC=1 |
| MFCD | MFCD00922198 |
| InChi | InChI=1S/C21H16FN3OS/c1-27(26)18-8-4-16(5-9-18)21-24-19(14-2-6-17(22)7-3-14)20(25-21)15-10-12-23-13-11-15/h2-13H,1H3,(H,24,25) |
| InChiKey | CDMGBJANTYXAIV-UHFFFAOYSA-N |
| CID | 176155 |
| Short Description | p38 MAPK inhibitor |
References
- PC Singhal et al. Role of P38 Mitogen-Activated Protein Kinase Phosphorylation and Fas-Fas Ligand Interaction in Morphine-Induced Macrophage Apoptosis. J. Immunol. 2002, 168, 4025-4033.
- PR Young et al. Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J. Biol. Chem. 1997, 272, 12116-12121.
- H Kankaanranta et al. SB 203580, an Inhibitor of p38 Mitogen-Activated Protein Kinase, Enhances Constitutive Apoptosis of Cytokine-Deprived Human Eosinophils. J. Pharm. Exp. Ther. 1999, 290, 2, 621-628.
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