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Binimetinib
- MEK162
- Soluble in DMSO
- MF: C17H15BrF2N4O3
- MW: 441.23
Description
Binimetinib is a potent, selective, non-ATP-competitive and orally available allosteric inhibitor of MEK1 and MEK2.
More Information
| Parent CAS No. | 606143-89-9 |
|---|---|
| Chemical Name | 5-(4-Bromo-2-fluorophenylamino)-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzo[d]imidazole-6-carboxamide |
| SMILES | C1C(C(NOCCO)=O)=C(NC2C(F)=CC(Br)=CC=2)C(F)=C2N=CN(C)C=12 |
| MFCD | MFCD22124525 |
| InChi | InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26) |
| InChiKey | ACWZRVQXLIRSDF-UHFFFAOYSA-N |
| CID | 10288191 |
| Short Description | MEK1/2 inhibitor |
References
- AL Patrice et al. Abstract 2515: Preclinical Development of ARRY-162, A Potent and Selective MEK 1/2 Inhibitor. Cancer Res 15 April 2010; 70 (8_Supplement): 2515.
- PA Ascierto et al. MEK162 for patients with advanced melanoma harbouring NRAS or Val600 BRAF mutations: a non-randomised, open-label phase 2 study. Lancet Oncol. 2013 Mar;14(3):249-56.
- B Tran et al. The discovery and development of binimetinib for the treatment of melanoma. Expert Opin Drug Discov. 2020 Jul;15(7):745-754.
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