RDEA119
- Refametinib - BAY 869766
- Optical Purity: 99% e.e.
- Soluble in DMSO
- MF: C19H20F3IN2O5S
- MW: 572.34
Description
RDEA119 is a potent, highly selective and orally-bioavailable small molecule allosteric MEK inhibitor with IC50 at low nM.
More Information
| Parent CAS No. | 923032-37-5 |
|---|---|
| Chemical Name | (S)-N-(3,4-Difluoro-2-(2-fluoro-4-iodophenylamino)-6-methoxyphenyl)-1-(2,3-dihydroxypropyl)cyclopropane-1-sulfonamide |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1(OC)C(NS(=O)(=O)C2(CC2)C[C@H](O)CO)=C(NC2C(F)=CC(I)=CC=2)C(F)=C(F)C=1 |&1:12,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28,29)19(4-5-19)8-11(27)9-26/h2-3,6-7,11,24-27H,4-5,8-9H2,1H3/t11-/m0/s1 |
| InChiKey | RDSACQWTXKSHJT-NSHDSACASA-N |
| CID | 44182295 |
| Short Description | MEK inhibitor |
References
- A Maderna et al. N-(ARYLAMINO)-SULFONAMIDE Inhibitors of MEK. 2009 Patent WO2007014011A3.
- B Quart et al. Preparation of phenylaminophenylsulfonamides for treatment of cancer and inflammatory disease. 2009, Patent WO 2009129246A2.
- C Iverson et al. RDEA119/BAY 869766: a potent, selective, allosteric inhibitor of MEK1/2 for the treatment of cancer. Cancer Res. 2009 Sep 1;69(17):6839-47.
Related Products
| AXON ID | NAME | FROM PRICE |
|---|---|---|
| 1122 | SL 327 |
From $88.00 |
| 1223 | PD98059 |
From $88.00 |
| 1368 | PD184352 |
From $88.00 |
| 1408 | PD0325901 |
From $55.00 |
| 1516 | AZD6244 |
From $66.00 |
| 1761 | GSK 1120212 |
From $77.00 |
| 1808 | BIX02188-Me |
From $121.00 |
| 1809 | BIX 02189 |
From $121.00 |
| 1999 | AZD8330 |
From $115.50 |
| 2128 | Stem Cell 2i inhibitor Set |
From $99.00 |
| 2129 | Stem Cell 3i inhibitor Set |
From $143.00 |
| 2520 | U 0126 |
From $99.00 |
| 3059 | GW 284543 hydrochloride |
From $104.50 |
| 3346 | BIX02188 |
From $121.00 |
| 3697 | Binimetinib |
From $66.00 |
| 4148 | GDC-0973 |
From Inquiry |
| 4217 | AS-703026 |
From Inquiry |
| 5009 | Stem Cell 4i inhibitor Set |
From $187.00 |
| 5010 | Naive Stem Cell NHSM inhibitor Set |
From $253.00 |
| 5011 | Naive Stem Cell 5i inhibitor Set |
From $220.00 |
