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Omaveloxolone
- RTA 408
Axon 2497
CAS:
1474034-05-3
- Optical Purity: Optically pure
- Soluble in DMSO
- MF: C33H44F2N2O3
- MW: 554.71
Description
Omaveloxolone (RTA-408) is a synthetic triterpenoid activator of NRF2 signaling with anti-inflammatory activity. It promotes antioxidant response element-dependent transcription and suppresses NF-κB-linked inflammatory signaling.
NRF2 controls cytoprotective antioxidant, detoxification and mitochondrial stress responses through KEAP1-regulated transcriptional programs. Omaveloxolone is relevant for studying oxidative stress, mitochondrial dysfunction, inflammation and neurodegenerative disease mechanisms.
Key Features
- NRF2 pathway activator
- Synthetic triterpenoid antioxidant-response modulator
- Suppresses NF-κB-related inflammatory signaling
- Clinically relevant pharmacology in oxidative stress and mitochondrial disease contexts
Applications
- NRF2/KEAP1 pathway research
- Oxidative stress and mitochondrial dysfunction studies
- Inflammation and cytoprotection assays
- Neurodegeneration and metabolic stress models
More Information
| Parent CAS No. | 1474034-05-3 |
|---|---|
| Chemical Name | N-((4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicen-4a-yl)-2,2-difluoropropanamide |
| SMILES | CC1(C)C[C@]2([H])[C@@](NC(C(F)(F)C)=O)(CC[C@@]3(C)[C@]4(C)CC[C@@]5([H])C(C)(C)C(=O)C(C#N)=C[C@]5(C)C4=CC(=O)[C@@]32[H])CC1 |&1:4,6,16,18,22,33,39,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C33H44F2N2O3/c1-27(2)11-13-33(37-26(40)32(8,34)35)14-12-31(7)24(20(33)17-27)21(38)15-23-29(5)16-19(18-36)25(39)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3,(H,37,40)/t20-,22-,24-,29-,30+,31+,33-/m0/s1 |
| InChiKey | RJCWBNBKOKFWNY-IDPLTSGASA-N |
| CID | 71811910 |
| Short Description | NRF2 acitivator |
Omaveloxolone (RTA-408)
NRF2 pathway activator
Omaveloxolone
RTA-408
NRF2 acitivator
RTA 408
RTA408
NF-E2L2
nuclear factor erythroid 2-related factor 2
NRF2 pathway
JNK
Activator
NF-κB signaling
NRF2/KEAP1 pathway research
Oxidative stress and mitochondrial dysfunction studies
Inflammation and cytoprotection assays
Neurodegeneration and metabolic stress models
mitochondrial function
oxidative stress
inflammation
neurodegeneration
metabolism
signal transduction
transcriptional regulation
DNA-RNA
Transcription Factors
ROS
CAS 1474034-05-3
Axon Medchem
Axon 2497
Supplier
Vendor
References
- S.A. Reisman et al. Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis. Radiat Res. 2014 May;181(5):512-20.
- B.L. Probst et al. RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity. PLoS One. 2015 Apr 21;10(4):e0122942.
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