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Clindamycin
- Dalacine - U 21251
- Soluble in DMSO
- MF: C18H33ClN2O5S
- MW: 424.98
Description
Clindamycin is a lincosamide antibiotic and bacterial protein synthesis inhibitor. It binds the 50S ribosomal subunit and inhibits peptidyltransferase-associated steps in bacterial translation.
Clindamycin is used to study ribosomal protein synthesis inhibition, antibacterial susceptibility and resistance mechanisms in Gram-positive and anaerobic bacterial models.
Key Features
- Lincosamide antibiotic
- Inhibits bacterial protein synthesis
- Targets the 50S ribosomal subunit
- Relevant to Gram-positive and anaerobic antibacterial research
Applications
- Bacterial translation assays
- Antimicrobial susceptibility testing
- Ribosomal resistance mechanism studies
- Antibacterial pharmacology models
More Information
| Parent CAS No. | 18323-44-9 |
|---|---|
| Chemical Name | (2S,4R)-N-((1S,2S)-2-chloro-1-((2R,3R,4S,5R,6R)-3,4,5-trihydroxy-6-(methylthio)tetrahydro-2H-pyran-2-yl)propyl)-1-methyl-4-propylpyrrolidine-2-carboxamide |
| extra_info | . |
| MFCD | MFCD00072005 |
| Short Description | Antibiotic |
References
- JG Bartlett et al. Clindamycin-associated colitis due to a toxin-producing species of Clostridium in hamsters. J. Infect. Diseases 1977, 136(5), 701-705.
- J Sutcliffe, A Tait-Kamradt, and L Wondrack. Streptococcus pneumoniae and Streptococcus pyogenes resistant to macrolides but sensitive to clindamycin: a common resistance pattern (...). Antimicrob. Agents Chemother. 1996, 40(8), 1817-1824.
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