Acyltransferases

The class of acylgroup transferring enzymes includes a multitude of substrate specific enzymes. For example, diacylglycerol O-acyltransferase 1 (DGAT1; EC 2.3.1.20) catalyzes the final step of the synthesis of triglycerides (TG) and plays a critical role in dietary fat absorption in the small intestine. Therefore, it is a potential therapeutic target for treatment of obesity and related metabolic diseases[1]. The co-enzyme Acyl-CoA is the donor substrate of the acetyl group that is transferred to the diglyceride substrates of DGAT1.


[1] Y. Hiramine, T. Tanabe. Characterization of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme of human small intestine. J. Physiol. Biochem. 2011, 67, 259-264.

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Axon ID Name Description From price
3743 (R)-HTS-3 hydrochloride First potent, selective, and cell-active LPCAT3 inhibitor €150.00
2059 A 922500 Highly potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor €105.00
1490 Anacardic acid A HAT inhibitor €60.00
2960 ATR-101 Potent, selective, and orally active ACAT1 inhibitor €145.00
2042 Azithromycin Macrolide antibiotic; Binds the 50S ribosomal subunit €50.00
2506 BMS 303141 Cell-permeable ATP-citrate lyase (ACL) inhibitor €90.00
1781 C 646 HAT inhibitor (p300/CBP selective) €60.00
3445 Clarithromycin Macrolide antibiotic; Binds the 50S ribosomal subunit €50.00
2063 Clindamycin Inhibitor of peptidyl transferase; Antibiotic €75.00
2765 CPTH2 HAT inhibitor (Gcn5p specific) €125.00
2568 EML 425 Potent reversible dual inhibitor of CBP and p300 (HAT/KAT3) €95.00
3823 Ervogastat Potent and selective diacylglycerol acyltransferase 2 (DGAT-2) inhibitor €160.00
2208 Gallic acid Multi-affinity drug. Antioxidant. €50.00
4127 GNE-781 Highly potent, selective, and orally bioavailable CBP inhibitor €160.00
3667 Homoharringtonine Protein synthesis inhibitor; Binds the 60S ribosomal subunit €100.00
2212 IWP L6 Highly potent porcupine (Porcn) inhibitor €130.00
2510 IWR-1-endo Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 €90.00
3959 JG-2016 First inhibitor of the HAT1 enzyme complex €140.00
2319 L 002 Inhibitor of p300 HAT (KAT3B) and p53 acetylation €80.00
3296 LEI-301 Potent phospholipase A and acyltransferase (PLAAT) inhibitor €140.00
2048 Linezolid Protein synthesis inhibitor; antibiotic €80.00
4011 MC4171 First-in-class potent and selective KAT8 inhibitor  Recently added €130.00
1785 MG 149 HAT inhibitor (Tip60 and MOZ specific) €90.00
1762 PNU 100480 Ribosomal peptidyl transferase center (PTC) inhibitor €60.00
2299 Remodelin Potent NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic cells via microtubule reorganization €90.00
3554 RP 70676 Potent and orally bioavailable ACAT inhibitor €210.00
2035 RU-SKI 43 hydrochloride Hedgehog acyltransferase (HHAT) inhibitor blocks Shh signaling €110.00
2673 RUSKI-201 dihydrochloride Sonic HHAT inhibitor lacking off-target cytotoxicity €135.00
2606 Solithromycin Fluoroketolide antibiotic €135.00
2835 SPT Imidazopyridine 1 Potent serine palmitoyl transferase (SPT) inhibitor €120.00

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