Acyltransferases

Acyltransferases

The class of acylgroup transferring enzymes includes a multitude of substrate specific enzymes. For example, diacylglycerol O-acyltransferase 1 (DGAT1; EC 2.3.1.20) catalyzes the final step of the synthesis of triglycerides (TG) and plays a critical role in dietary fat absorption in the small intestine. Therefore, it is a potential therapeutic target for treatment of obesity and related metabolic diseases. The co-enzyme Acyl-CoA is the donor substrate of the acetyl group that is transferred to the diglyceride substrates of DGAT1.

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More About Acyltransferases

The class of acylgroup transferring enzymes includes a multitude of substrate specific enzymes. For example, diacylglycerol O-acyltransferase 1 (DGAT1; EC 2.3.1.20) catalyzes the final step of the synthesis of triglycerides (TG) and plays a critical role in dietary fat absorption in the small intestine. Therefore, it is a potential therapeutic target for treatment of obesity and related metabolic diseases[1]. The co-enzyme Acyl-CoA is the donor substrate of the acetyl group that is transferred to the diglyceride substrates of DGAT1.

[1] Y. Hiramine, T. Tanabe. Characterization of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme of human small intestine. J. Physiol. Biochem. 2011, 67, 259-264.

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