Acyltransferases
The class of acylgroup transferring enzymes includes a multitude of substrate specific enzymes. For example, diacylglycerol O-acyltransferase 1 (DGAT1; EC 2.3.1.20) catalyzes the final step of the synthesis of triglycerides (TG) and plays a critical role in dietary fat absorption in the small intestine. Therefore, it is a potential therapeutic target for treatment of obesity and related metabolic diseases[1]. The co-enzyme Acyl-CoA is the donor substrate of the acetyl group that is transferred to the diglyceride substrates of DGAT1.
[1] Y. Hiramine, T. Tanabe. Characterization of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme of human small intestine. J. Physiol. Biochem. 2011, 67, 259-264.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 3743 | (R)-HTS-3 hydrochloride | First potent, selective, and cell-active LPCAT3 inhibitor | €150.00 | |
| 2059 | A 922500 | Highly potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor | €105.00 | |
| 1490 | Anacardic acid A | HAT inhibitor | €60.00 | |
| 2960 | ATR-101 | Potent, selective, and orally active ACAT1 inhibitor | €145.00 | |
| 2042 | Azithromycin | Macrolide antibiotic; Binds the 50S ribosomal subunit | €50.00 | |
| 2506 | BMS 303141 | Cell-permeable ATP-citrate lyase (ACL) inhibitor | €90.00 | |
| 1781 | C 646 | HAT inhibitor (p300/CBP selective) | €60.00 | |
| 3445 | Clarithromycin | Macrolide antibiotic; Binds the 50S ribosomal subunit | €50.00 | |
| 2063 | Clindamycin | Inhibitor of peptidyl transferase; Antibiotic | €75.00 | |
| 2765 | CPTH2 | HAT inhibitor (Gcn5p specific) | €125.00 | |
| 4389 | CTPB | HAT activator (p300 selective) | Recently added | €140.00 |
| 2568 | EML 425 | Potent reversible dual inhibitor of CBP and p300 (HAT/KAT3) | €95.00 | |
| 3823 | Ervogastat | Potent and selective diacylglycerol acyltransferase 2 (DGAT-2) inhibitor | €160.00 | |
| 2208 | Gallic acid | Multi-affinity drug. Antioxidant. | €50.00 | |
| 4127 | GNE-781 | Highly potent, selective, and orally bioavailable CBP inhibitor | €160.00 | |
| 3667 | Homoharringtonine | Protein synthesis inhibitor; Binds the 60S ribosomal subunit | €100.00 | |
| 2212 | IWP L6 | Highly potent porcupine (Porcn) inhibitor | €130.00 | |
| 4370 | IWP-2 | Inhibitor of Wnt signaling by inhibiting porcupine (Porcn) | Recently added | €130.00 |
| 2510 | IWR-1-endo | Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2 | €95.00 | |
| 3959 | JG-2016 | First inhibitor of the HAT1 enzyme complex | €140.00 | |
| 2319 | L 002 | Inhibitor of p300 HAT (KAT3B) and p53 acetylation | €80.00 | |
| 3296 | LEI-301 | Potent phospholipase A and acyltransferase (PLAAT) inhibitor | €140.00 | |
| 2048 | Linezolid | Protein synthesis inhibitor; antibiotic | €80.00 | |
| 4011 | MC4171 | First-in-class potent and selective KAT8 inhibitor | €130.00 | |
| 1785 | MG 149 | HAT inhibitor (Tip60 and MOZ specific) | €90.00 | |
| 1762 | PNU 100480 | Ribosomal peptidyl transferase center (PTC) inhibitor | €60.00 | |
| 2299 | Remodelin | Potent NAT 10 inhibitor that mediates nuclear shape rescue in laminopathic cells via microtubule reorganization | €90.00 | |
| 3554 | RP 70676 | Potent and orally bioavailable ACAT inhibitor | €210.00 | |
| 2035 | RU-SKI 43 hydrochloride | Hedgehog acyltransferase (HHAT) inhibitor blocks Shh signaling | €110.00 | |
| 2673 | RUSKI-201 dihydrochloride | Sonic HHAT inhibitor lacking off-target cytotoxicity | €135.00 | |