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PNU 100480
- PF 02341272 - U 100480 - Sutezolid
Axon 1762
CAS:
168828-58-8
Purity:
99%
- Soluble in DMSO
- MF: C16H20FN3O3S
- MW: 353.41
Description
Antituberculosis (anti-TB) agent under clinical development; potent inhibitor of bacterial protein biosynthesis by interfering with the binding of initiator fMet-tRNA(i)(Met) to the ribosomal peptidyltransferase P-site
More Information
| Parent CAS No. | 168828-58-8 |
|---|---|
| Chemical Name | (S)-N-((3-(3-fluoro-4-thiomorpholinophenyl)-2-oxooxazolidin-5-yl)methyl)acetamide |
| extra_info | . |
| MFCD | MFCD00937821 |
| Short Description | Ribosomal PTC inhibitor |
References
- KN Williams et al. Promising Antituberculosis Activity of the Oxazolidinone PNU-100480 Relative to That of Linezolid in a Murine Model. Antimicrob Agents Chemother. 2009, 53(4), 1314–1319.
- KN Williams et al. Addition of PNU-100480 to first-line drugs shortens the time needed to cure murine tuberculosis. Am. J. Respir. Crit. Care Med. 2009, 180(4), 371-6.
- U Patel et al. Oxazolidinones mechanism of action: inhibition of the first peptide bond formation. J. Biol. Chem. 2001, 276(40), 37199-205.
- CE Barry and JS Blanchard. The Chemical Biology of New Drugs in Development for Tuberculosis. Curr. Opin. Chem. Biol. 2010, 14(4), 456–466.
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