ATP citrate lyase (ACL; EC 2.3.3. 8) is a cytosolic enzyme that catalyzes the synthesis of acetyl-CoA and oxaloacetate using citrate, CoA, and ATP as substrates and Mg²⁺ as a necessary cofactor, and it is expressed in lipogenic tissues such as liver and adipose[1]. In mammals, the formation of acetyl-CoA is an essential step for the de novo synthesis of fatty acid (FA) and cholesterol for converting the carbohydrate carbon energy source into lipids. Hence, it has been thought that ACL inhibition would be beneficial for the treatment of obesity and dyslipidemia through the simultaneous inhibition of endogenous synthesis of FA and cholesterol[2]. Interestingly, it was found that ACL is also required for increases in histone acetylation in response to growth factor stimulation and during differentiation, and that glucose availability can affect histone acetylation in an ACL-dependent manner[3].