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L 002
- NSC 764414
- Soluble in DMSO
- MF: C15H15NO5S
- MW: 321.35
Description
L 002 (NSC764414) is an inhibitor of the p300 histone acetyltransferase (KAT3B) with an IC50 value of 1.98 μM in vitro. It inhibits acetylation of histones and p53, suppresses STAT3 activation in cell-based assays and reduces tumor growth in MDA-MB-468 triple-negative breast cancer xenografts.
p300/CBP-mediated acetylation regulates chromatin accessibility, transcriptional activation and oncogenic signaling networks. L 002 is useful for studying histone acetyltransferase pharmacology, transcriptional coactivator function and cancer epigenetics.
Key Features
- p300/KAT3B histone acetyltransferase inhibitor
- IC50: 1.98 μM in vitro
- Inhibits histone and p53 acetylation
- Suppresses STAT3 activation and TNBC xenograft growth
Applications
- Epigenetic enzyme research
- p300 acetyltransferase assays
- Cancer transcriptional signaling studies
- Triple-negative breast cancer model research
More Information
| Parent CAS No. | 321695-57-2 |
|---|---|
| Chemical Name | 4-(4-methoxyphenylsulfonyloxyimino)-2,6-dimethylcyclohexa-2,5-dienone |
| SMILES | C1(=O)C(C)=C/C(=NOS(C2=CC=C(OC)C=C2)(=O)=O)/C=C1C |
| MFCD | N.A. |
| InChi | InChI=1S/C15H15NO5S/c1-10-8-12(9-11(2)15(10)17)16-21-22(18,19)14-6-4-13(20-3)5-7-14/h4-9H,1-3H3 |
| InChiKey | VEWFTYOFWIXCIO-UHFFFAOYSA-N |
| CID | 2221149 |
| Short Description | p300 HAT inhibitor |
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