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NSC 348884
- Moderately soluble in DMSO
- MF: C38H40N10
- MW: 636.79
Description
NSC 348884 is a putative nucleophosmin 1 (NPM1) inhibitor originally reported to disrupt NPM oligomerization, increase p53 signaling and induce apoptosis.
NSC 348884 is used in NPM1 and nucleolar-stress research, but later studies have questioned whether its cytotoxicity is directly caused by inhibition of NPM oligomer formation. It should therefore be treated as a phenotypic probe with mechanism-validation controls.
Key Features
- Reported inhibitor of NPM1 oligomerization
- Induces p53-associated apoptotic responses
- Produces antiproliferative effects in cancer-cell models
- Mechanism should be confirmed with orthogonal approaches
Applications
- NPM1 and nucleolar-stress research
- p53 pathway and apoptosis studies
- Cancer-cell proliferation assays
- Mechanism-of-action validation experiments
More Information
| Parent CAS No. | 81624-55-7 |
|---|---|
| Chemical Name | N,N,N',N'-Tetrakis-(5-methyl-1H-benzoimidazol-2-ylmethyl)-ethane-1,2-diamine |
| SMILES | C(N(CC1=NC2C=C(C)C=CC=2N1)CCN(CC1=NC2C=C(C)C=CC=2N1)CC1NC2C=CC(C)=CC=2N=1)C1NC2C=CC(C)=CC=2N=1 |
| MFCD | MFCD12546137 |
| InChi | InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46) |
| InChiKey | KZOLQEUQAFTQFM-UHFFFAOYSA-N |
| CID | 335974 |
| Short Description | NPM inhibitor |
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