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Pifithrin-β
- PFT-β - Z-2-035II
- Soluble in DMSO
- MF: C16H16N2S
- MW: 268.38
Description
Pifithrin-β is the condensation product of the p53 protein inhibitor Pifithrin-α (Axon 1871). Pifithrin-α is unstable in vitro and is rapidly converted to Pifithrin-β.
More Information
| Parent CAS No. | 60477-34-1 |
|---|---|
| Chemical Name | 2-(4-Methylphenyl)-5,6,7,8-tetrahydroimidazo[2,1-b][1,3]benzothiazole |
| SMILES | C1CC2SC3=NC(C4C=CC(C)=CC=4)=CN3C=2CC1 |
| MFCD | N.A. |
| InChi | InChI=1S/C16H16N2S/c1-11-6-8-12(9-7-11)13-10-18-14-4-2-3-5-15(14)19-16(18)17-13/h6-10H,2-5H2,1H3 |
| InChiKey | IMUKUMUNZJILCG-UHFFFAOYSA-N |
| CID | 443278 |
| Short Description | p53 inhibitor |
References
- N Pietrancosta et al. Novel cyclized Pifithrin-alpha p53 inactivators: synthesis and biological studies. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1561-4.
- N Pietrancosta et al. Imino-tetrahydro-benzothiazole derivatives as p53 inhibitors: discovery of a highly potent in vivo inhibitor and its action mechanism. J Med Chem. 2006 Jun 15;49(12):3645-52.
- MI Walton et al. An evaluation of the ability of pifithrin-alpha and -beta to inhibit p53 function in two wild-type p53 human tumor cell lines. Mol Cancer Ther. 2005 Sep;4(9):1369-77.
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