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JG-2016
- Soluble in DMSO and EtOH
- MF: C18H21ClN4O3
- MW: 376.84
Description
JG-2016 is the first inhibitor of the HAT1 enzyme complex with an IC50 value of 14.8 μM. JG-2016 showed relative specificity toward HAT1 compared to other acetyltransferases, suppressed the growth of human cancer cell lines, impaired enzymatic activity in cellulo, and interfered with tumor growth.
More Information
| Parent CAS No. | 2887480-87-5 |
|---|---|
| Chemical Name | 7-Chloro-8-ethyl-10-(2-isobutoxyethyl)benzo[g]pteridine-2,4(3H,10H)-dione |
| SMILES | C1(Cl)C(CC)=CC2N(CCOCC(C)C)C3=NC(=O)NC(=O)C3=NC=2C=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C18H21ClN4O3/c1-4-11-7-14-13(8-12(11)19)20-15-16(21-18(25)22-17(15)24)23(14)5-6-26-9-10(2)3/h7-8,10H,4-6,9H2,1-3H3,(H,22,24,25) |
| InChiKey | IOHJEWFKBRNJIO-UHFFFAOYSA-N |
| CID | 166558326 |
| Short Description | HAT1 inhibitor |
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