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CPTH2
- Soluble in DMSO
- MF: C14H14ClN3S
- MW: 291.8
Description
CPTH2 is a cell-permeable inhibitor of the histone acetyltransferase GCN5/KAT2A and a modulator of GCN5-dependent chromatin signaling. It reduces histone acetylation, including H3K14 acetylation, and alters transcriptional programs controlled by GCN5-containing complexes.
CPTH2 is used to investigate lysine acetylation, chromatin regulation and the biological consequences of suppressing GCN5 activity in yeast and mammalian cells. Because histone-acetyltransferase inhibitors can show context-dependent selectivity, direct acetylation and target-engagement readouts are recommended.
Key Features
- GCN5 histone acetyltransferase (HAT) inhibitor
- Reduces histone H3 acetylation
- Cell-permeable epigenetic probe
- Modulates GCN5-dependent transcription
Applications
- Histone acetylation & GCN5 biology
- Chromatin and transcription studies
- Epigenetic enzyme assays
- Cellular differentiation and proliferation research
More Information
| Parent CAS No. | 357649-93-5 |
|---|---|
| Chemical Name | 4-(4-Chlorophenyl)-2-(2-cyclopentylidenehydrazinyl)thiazole |
| SMILES | C1SC(N/N=C2/CCCC/2)=NC=1C1C=CC(Cl)=CC=1 |
| MFCD | MFCD02307488 |
| InChi | InChI=1S/C14H14ClN3S/c15-11-7-5-10(6-8-11)13-9-19-14(16-13)18-17-12-3-1-2-4-12/h5-9H,1-4H2,(H,16,18) |
| InChiKey | YYTHPXHGWSAKIZ-UHFFFAOYSA-N |
| CID | 25193530 |
| Short Description | GCN5 inhibitor |
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