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RU-SKI 43 hydrochloride
Axon 2035
- Parent CAS: 1043797-53-0
Purity:
99%
- Soluble in DMSO
- MF: C22H30N2O2S.HCl
- MW: 423.01
Description
RU-SKI 43 hydrochloride is a Hedgehog acyltransferase (HHAT) inhibitor that blocks Sonic Hedgehog (Shh) palmitoylation and reduces Hedgehog pathway signaling in vitro and in cellular systems.
HHAT-mediated palmitoylation is required for proper Hedgehog ligand maturation, secretion and pathway activity. RU-SKI 43 is useful for studying upstream control of Hedgehog signaling in developmental biology, stem-cell and cancer pathway models.
Key Features
- HHAT inhibitor
- Blocks Shh ligand palmitoylation
- Suppresses Hedgehog pathway signaling
- Targets upstream ligand-processing biology
Applications
- Hedgehog signaling assays
- Shh palmitoylation studies
- Developmental pathway research
- Cancer and stem-cell signaling models
More Information
| Parent CAS No. | 1043797-53-0 |
|---|---|
| Chemical Name | 2-(2-methylbutylamino)-1-(4-(m-tolyloxymethyl)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)ethanone hydrochloride |
| SMILES | C(=O)(N1C(COC2=CC=CC(C)=C2)C2C=CSC=2CC1)CNCC(C)CC.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C22H30N2O2S.ClH/c1-4-16(2)13-23-14-22(25)24-10-8-21-19(9-11-27-21)20(24)15-26-18-7-5-6-17(3)12-18;/h5-7,9,11-12,16,20,23H,4,8,10,13-15H2,1-3H3;1H |
| InChiKey | JBBKLHJLHRGJSQ-UHFFFAOYSA-N |
| CID | 90488982 |
| Short Description | HHAT inhibitor |
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