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JK184
- Soluble in DMSO and EtOH
- MF: C19H18N4OS
- MW: 350.44
Description
JK184 is a potent, downstream Hedgehog (Hh) signaling pathway antagonist and a microtubule depolymerizing agent. It serves as a valuable pharmacology tool, demonstrating robust antiproliferative and antitumor effects in both in vitro and in vivo translational disease models.
Hedgehog (Hh) pathway pharmacology drives critical discoveries in translational oncology and cellular disease models. JK184 serves as a precise dual-target chemical probe, supporting mechanistic studies of both Hh signaling and alcohol dehydrogenase (ADH) across biochemical, cellular, and in vivo assays.
Key Features
- Hedgehog (Hh) signaling antagonist
- IC50 30 nM for inhibition of Gli-dependent transcriptional activity
- Modulates Hedgehog-dependent signaling or biological activity
- Supports focused Hedgehog pathway studies in biochemical and cellular systems
Applications
- Hedgehog pharmacology and target-validation studies
- Mechanistic Hedgehog pathway and signaling assays
- Translational Oncology Research
- Enzymatic Modeling
More Information
| Parent CAS No. | 315703-52-7 |
|---|---|
| Chemical Name | N-(4-ethoxyphenyl)-4-(2-methylimidazo[1,2-a]pyridin-3-yl)thiazol-2-amine |
| SMILES | S1C=C(C2N3C(=NC=2C)C=CC=C3)N=C1NC1=CC=C(OCC)C=C1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H18N4OS/c1-3-24-15-9-7-14(8-10-15)21-19-22-16(12-25-19)18-13(2)20-17-6-4-5-11-23(17)18/h4-12H,3H2,1-2H3,(H,21,22) |
| InChiKey | ROYXIPOUVGDTAO-UHFFFAOYSA-N |
| CID | 1069686 |
| Short Description | Hedgehog inhibitor |
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